【2h】

IPD-IMGT/HLA Database

机译:IPD-IMGT / HLA数据库

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摘要

The IPD-IMGT/HLA Database, , currently contains over 25 000 allele sequence for 45 genes, which are located within the Major Histocompatibility Complex (MHC) of the human genome. This region is the most polymorphic region of the human genome, and the levels of polymorphism seen exceed most other genes. Some of the genes have several thousand variants and are now termed hyperpolymorphic, rather than just simply polymorphic. The IPD-IMGT/HLA Database has provided a stable, highly accessible, user-friendly repository for this information, providing the scientific and medical community access to the many variant sequences of this gene system, that are critical for the successful outcome of transplantation. The number of currently known variants, and dramatic increase in the number of new variants being identified has necessitated a dedicated resource with custom tools for curation and publication. The challenge for the database is to continue to provide a highly curated database of sequence variants, while supporting the increased number of submissions and complexity of sequences. In order to do this, traditional methods of accessing and presenting data will be challenged, and new methods will need to be utilized to keep pace with new discoveries.
机译:IPD-IMGT / HLA数据库目前包含45个基因的25,000个等位基因序列,这些基因位于人类基因组的主要组织相容性复合体(MHC)中。该区域是人类基因组中最多态的区域,可见的多态性水平超过了大多数其他基因。一些基因具有数千个变体,现在被称为超多态性,而不仅仅是简单的多态性。 IPD-IMGT / HLA数据库为该信息提供了一个稳定,高度可访问,用户友好的存储库,使科学界和医学界可以访问此基因系统的许多变异序列,这对于成功移植成果至关重要。当前已知的变体的数量以及所识别的新变体的数量的急剧增加,已经需要具有用于策展和发布的自定义工具的专用资源。数据库面临的挑战是如何继续提供高度精选的序列变体数据库,同时支持提交数量的增加和序列的复杂性。为此,将挑战传统的访问和呈现数据的方法,并且将需要利用新方法来跟上新发现。

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