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IPD-IMGT/HLA Database

机译：IPD-IMGT / HLA数据库

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摘要

The IPD-IMGT/HLA Database, http://www.ebi.ac.uk/ipd/imgt/hla/, currently contains over 25 000 allele sequence for 45 genes, which are located within the Major Histocompatibility Complex (MHC) of the human genome. This region is the most polymorphic region of the human genome, and the levels of polymorphism seen exceed most other genes. Some of the genes have several thousand variants and are now termed hyperpolymorphic, rather than just simply polymorphic. The IPD-IMGT/HLA Database has provided a stable, highly accessible, user-friendly repository for this information, providing the scientific and medical community access to the many variant sequences of this gene system, that are critical for the successful outcome of transplantation. The number of currently known variants, and dramatic increase in the number of new variants being identified has necessitated a dedicated resource with custom tools for curation and publication. The challenge for the database is to continue to provide a highly curated database of sequence variants, while supporting the increased number of submissions and complexity of sequences. In order to do this, traditional methods of accessing and presenting data will be challenged, and new methods will need to be utilized to keep pace with new discoveries.
机译：IPD-IMGT / HLA数据库，http://www.ebi.ac.uk/ipd/imgt/hla/，目前包含超过25 000个等位基因序列，用于45个基因，位于主要组织相容性复合物（MHC）内人类基因组。该区域是人类基因组最多的多态性区域，并且看到的多态性水平超过大多数其他基因。一些基因有几千种变体，现在被称为过度反对，而不是仅仅是多态的。 IPD-IMGT / HLA数据库为该信息提供了稳定，高度可访问的用户友好的存储库，提供了科学和医学群落访问该基因系统的许多变体序列，这对于成功的移植结果至关重要。当前已知的变体的数量以及正在识别的新变体数量的戏剧性增加需要具有定制工具的专用资源，用于策策和发布。数据库的挑战是继续提供高度策划的序列变体数据库，同时支持增加的提交数量和序列的复杂性。为此，传统的访问和呈现数据方法将受到挑战，并且需要使用新方法来跟上新发现。

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