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Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

机译：抑郁症-预防阿尔茨海默氏病痴呆症的目标尚未得到认可

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Depression can occur in three different stages in relation to the process of neurodegeneration in AD. Depression can be a predisposing risk factor occuring before the onset of AD pathology. It might also be an early sign of neurodegenerative changes or a prodromal symptom with or without cognitive deficits. Finally, it may occur at the more advanced dementia stage of AD. In every stage depression is an important accelerating factor contributing to the clinical progression and conversion from a preclinical state to MCI and to dementia.

机译：与AD中神经变性的过程有关，抑郁可以在三个不同阶段发生。抑郁可能是AD病理发作之前发生的诱发因素。这也可能是神经退行性变化的早期征兆或有或没有认知缺陷的前驱症状。最后，它可能发生在AD的晚期痴呆症阶段。在每个阶段，抑郁症都是重要的促进因素，可促进临床进展以及从临床前状态向MCI和痴呆的转化。

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期刊名称 Translational Psychiatry
作者
Forugh S. Dafsari; Frank Jessen;
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作者单位

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年(卷),期 2020(10),-1
年度 2020
页码 -1
总页数 13
原文格式 PDF
正文语种
中图分类精神病学;
关键词
Predictive markers; Pathogenesis; Diagnostic markers; Depression;

机译：预测标志物;发病机理;诊断标志物;抑郁;

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专利

1. Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease [J] . Forugh S. Dafsari, Frank Jessen Translational psychiatry. . 2020,第1期

机译：抑郁症 - 在阿尔茨海默病中预防痴呆症的低估靶标
2. Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Primary prevention of dementia in Alzheimer's disease: a perspective from prevention research in cardiovascular disease and stroke. [J] . Fillit H, Nash DT, Shineman D Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2009,第2期

机译：关于“预防痴呆症的路线图II。莱昂·塔尔研讨会2008”的评论。阿尔茨海默氏病痴呆症的一级预防：心血管疾病和中风预防研究的观点。
3. Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Centers of excellence in Alzheimer's disease: it is time to better integrate patient care and clinical research to improve the prevention and treatment of Alzheimer's disease. [J] . Doody RS Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2009,第2期

机译：关于“预防痴呆症的路线图II。莱昂·塔尔研讨会2008”的评论。阿尔茨海默氏病卓越中心：现在是时候更好地整合患者护理和临床研究，以改善阿尔茨海默氏病的预防和治疗了。
4. Application of Statecharts and Agent Based Modelling in Representing Clinically Relevant Aspects of Dementia and Depression in Alzheimer's Disease [C] . Victor VICKLAND, Henry BRODATY The 12th world multi-conference on systemics, cybernetics and informatics : Proceedings . 2008

机译：状态图和基于主体的建模在代表阿尔茨海默氏病痴呆和抑郁症的临床相关方面的应用
5. Serum lipids and statin therapy in relation to Alzheimer's disease: Exploring the relationship between elevated serum cholesterol levels and Alzheimer's disease dementia. [D] . Brinker, Krystin. 2011

机译：与阿尔茨海默氏病有关的血脂和他汀类药物治疗：探讨血清胆固醇水平升高与阿尔茨海默氏病痴呆症之间的关系。
6. Association of Late Life Depression (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer’s Disease: Literature Review on Current Evidences Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia [O] . Chih-Yun Kuo, Ivo Stachiv, Tomas Nikolai 2020

机译：晚年抑郁症协会（非）患有痴呆症和阿尔茨海默病的可修改风险和保护因素：关于现有证据预防干预和痴呆症预防治疗的未来趋势的文献综述
7. Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease [O] . Forugh S. Dafsari, Frank Jessen 2020

机译：抑郁症 - 在阿尔茨海默病中预防痴呆症的低估靶标
8. Recognition and Initial Assessment of Alzheimer's Disease and Related Dementias.Clinical Practice Guideline Number 19; Early Identification of Alzheimer's Disease and Related Dementias. Quick Reference Guide for Clinicians Number 19; Early Alzheimer's Dis [R] . Costa, P. T., Williams, T. F., Albert, M. S., 1996

机译：阿尔茨海默病和相关痴呆的认可和初步评估。临床实践指南第19号;阿尔茨海默病及相关痴呆的早期鉴定。临床医生快速参考指南第19号;早期阿尔茨海默氏症

Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease

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