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首页> 美国卫生研究院文献>Pharmaceuticals >Oral l-Cysteine Supplementation Enhances the Long Term-Effect of Topical Basic Fibroblast Growth Factor (bFGF) in Reducing the Corneal Haze after Photorefractive Keratectomy in Myopic Patients
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Oral l-Cysteine Supplementation Enhances the Long Term-Effect of Topical Basic Fibroblast Growth Factor (bFGF) in Reducing the Corneal Haze after Photorefractive Keratectomy in Myopic Patients

机译：口服L-半胱氨酸补充剂提高了近视患者光焦焦肿后减少角膜雾度降低角膜雾度的长期效应

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We aimed at evaluating the long-term effects of -cysteine oral supplementation to basic fibroblast growth factor (bFGF) eye-drops on corneal re-epithelization and transparency in myopic patients subjected to photorefractive keratectomy (PRK). Forty patients subjected to bilateral PRK for myopia were enrolled and randomly divided into two groups receiving an additional therapy together with the standard postoperative treatment consisting in local tobramycin 0.3%, dexamethasone 0.1%, diclofenac 0.1%, and 0.2% hyaluronate. Group 1 included 20 patients (11 males and 9 females; 34.09 ± 8 years of age) receiving only bFGF eye-drops (10 μg/10 μL) four times a day for 7 days starting from the day of surgery; Group 2 included 20 patients (12 males and 8 females; 37.35 ± 11.5 years of age) who were postoperatively administered with topical basic fibroblast growth factor (bFGF; 10 μg/10 μL) four times a day for 7 days plus oral cysteine supplementation (500 mg/capsule) once a day for 15 days, starting 7 days before PRK. Patients were followed-up for 12 months. Clinical ophthalmologic parameters were recorded for all the 80 examined eyes. The corneal transparency was evaluated in vivo by slit lamp and confocal microscopy. The data showed that: (a) the corneal haze occurred in a smaller percentage of the patients who were postoperatively administered with topical bFGF plus oral cysteine supplementation (Group 2) compared to patients who received only bFGF (Group 1); (b) at 6 months of follow-up, the stromal mean image brightness of the patients belonging to Group 2 was significantly lower than that of the Group 1 ( < 0.03), and, interestingly, the difference was even more evident at 12 month from the treatment ( < 0.001). Moreover, the final mean of the spherical equivalent refraction was −0.06 ± 0.2 D in Group 1 and −0.08 ± 0.3 D in Group 2, whereas the final uncorrected distance visual acuity (UDVA) was equal or superior to 20/25 in 100% of eyes in both Group 1 and 2. Post refractive patients can benefit from the administration of -cysteine before the surgery and in association with bFGF in the early postoperative period, showing a faster corneal re-epithelization able to prevent corneal haze in the long-term recovery.
机译：我们旨在评估 - 对近视患者的角膜再上皮细胞和透明性进行近视患者的基本成纤维细胞生长因子（BFGF）滴眼症的长期效应。将患有双侧PRK进行近视的四十名患者被纳入并随机分为两组，该组接受额外疗法，其标准术后处理包括在局部杂草0.3％，地塞米松0.1％，双氯芬酸0.1％和0.2％透明质酸盐。第1组包括20名患者（11名男性和9名女性; 34.09±8岁）仅在手术当天开始只接受每天7天的BFGF滴眼液（10μg/10μl）;第2组包括20名患者（12名男性和8名女性; 37.35±11.5岁），术后术后施用局部碱性成纤维细胞生长因子（BFGF;10μg/10μl）每天7天加上口服半胱氨酸补充剂（ 500毫克/胶囊）每天一次15天，在PRK前7天开始。患者随访12个月。所有80只检查眼睛都记录了临床眼科参数。通过狭缝灯和共聚焦显微镜在体内评估角膜透明度。数据显示：（a）与仅接受BFGF的患者（第1组）的患者，术后术后患者的患者发生较小百分比的患者的角膜雾度。 （b）在6个月的随访中，属于第2组的患者的基质平均图像亮度显着低于第1组（<0.03），有趣的是，在12个月内甚至更加明显从治疗（<0.001）。此外，第1组球形当量折射的最终平均值为-0.06±0.2d，2组中-0.08±0.3d，而最终未矫正的距离视力（UDVA）等于或优于20/25以100％折射患者的眼睛在屈光术后可以从手术前和术后早期的BFGF与BFGF一起受益，显示出更快的角膜再上皮，能够预防长期的角膜雾度术语恢复。

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