• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Membranes >Recent Experiments Support a Microemulsion Origin of Plasma Membrane Domains: Dependence of Domain Size on Physical Parameters
【2h】

Recent Experiments Support a Microemulsion Origin of Plasma Membrane Domains: Dependence of Domain Size on Physical Parameters

机译：最近的实验支持血浆膜域的微乳液起源：域大小对物理参数的依赖性

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is widely, but not universally, believed that the lipids of the plasma membrane are not uniformly distributed, but that “rafts” of sphingolipids and cholesterol float in a “sea” of unsaturated lipids. The physical origin of such heterogeneities is often attributed to a phase coexistence between the two different domains. We argue that this explanation is untenable for several reasons. Further, we note that the results of recent experiments are inconsistent with this picture. However, they are quite consistent with an alternate explanation, namely, that the plasma membrane is a microemulsion of the two kinds of regions. To show this, we briefly review a simplified version of this theory and its phase diagram. We also explicate the dependence of the predicted domain size on four physical parameters. They are the energy cost of gradients in the composition, the spontaneous curvature of the membrane, its bending modulus and its surface tension. Taking values of the latter two from experiment, we obtain domain sizes for several different cell types that vary from 58 to 88 nm.
机译：它广泛而不是普遍的，认为血浆膜的脂质不均匀分布，但鞘脂的“筏”和胆固醇漂浮在不饱和脂质的“海”中。这种异质性的物理来源通常归因于两个不同结构域之间的相位共存。我们认为这一解释是近期理由的。此外，我们注意到最近实验的结果与这张照片不一致。然而，它们与替代解释相当一致，即，血浆膜是两种区域的微乳液。为了展示这一点，我们简要介绍了这个理论的简化版本及其相图。我们还会在四个物理参数上阐明预测域大小的依赖。它们是组合物中梯度的能量成本，膜的自发曲率，其弯曲模量及其表面张力。从实验中取出后两种的值，我们获得几种不同的细胞类型的域尺寸，从58到88nm之间变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号