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首页> 美国卫生研究院文献>Advanced Science >A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress
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A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress

机译：一种浮肿的微流体新生儿肺部辅助装置用于支撑呼吸窘迫中的早产新生儿

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Premature neonates suffer from respiratory morbidity as their lungs are immature, and current supportive treatment such as mechanical ventilation or extracorporeal membrane oxygenation causes iatrogenic injuries. A non‐invasive and biomimetic concept known as the “artificial placenta” (AP) would be beneficial to overcome complications associated with the current respiratory support of preterm infants. Here, a pumpless oxygenator connected to the systemic circulation supports the lung function to relieve respiratory distress. In this paper, the first successful operation of a microfluidic, artificial placenta type neonatal lung assist device (LAD) on a newborn piglet model, which is the closest representation of preterm human infants, is demonstrated. This LAD has high oxygenation capability in both pure oxygen and room air as the sweep gas. The respiratory distress that the newborn piglet is put under during experimentation, repeatedly and over a significant duration of time, is able to be relieved. These findings indicate that this LAD has a potential application as a biomimetic artificial placenta to support the respiratory needs of preterm neonates.
机译：早产新生儿患有呼吸道发病率，因为它们的肺不成熟，并且电流支持处理如机械通气或体外膜氧合，导致原因损伤。作为“人工胎盘”（AP）称为“人工胎盘”（AP）的非侵入性和仿生概念将有利于克服与早产儿的目前呼吸系统相关的并发症。这里，连接到全身循环的浮出氧气器支持肺功能以缓解呼吸窘迫。本文阐述了新出生小猪模型的微流体，人工胎盘型新生儿肺辅助装置（LAD）的首次成功操作，这是早产儿的最接近人婴儿的最接近的代表性。该LAD在纯氧和室内空气中具有高氧合能力作为扫描气体。新生仔猪在实验期间，重复和在大量时间内进行呼吸窘迫，能够被解除。这些发现表明，该小伙子具有潜在的应用作为仿生人工胎盘，以支持早产新生儿的呼吸需求。

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