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Clinical Significance of ROMs OXY SHp and HMGB-1 in Canine Leishmaniosis

机译:Canine Leishmaniaisis的ROMOXYSHOP和HMGB1的临床意义

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摘要

The reactive oxidative metabolites (ROMs), the antioxidant barrier (OXY), the ratio between ROMs and OXY (OSi), thiol groups of plasma compounds (SHp) and the concentration of High Mobility Group Box-1 protein (HMGB-1) were evaluated in dogs naturally infected by Leishmania spp., correlating them with hematological and biochemical parameters. Results showed a significant increase in SHp levels, and a negative correlation between ROMs and the number of red blood cells, and between HGMB-1 and SHp, suggesting the potential role of oxidative stress in the pathogenesis of canine leishmaniosis.
机译:反应性氧化代谢物(ROM),抗氧化剂屏障(氧),ROM和氧(OSI)之间的比例,血浆化合物(SHP)的硫醇基团和高迁移率组箱-1-1蛋白(HMGB-1)的浓度在由Leishmania SPP自然感染的狗中评估。,将它们与血液学和生化参数相关联。结果表明,SHP水平显着增加,ROM和红细胞数量之间的负相关性,以及HGMB-1和SHP之间的负相关性,表明氧化胁迫在犬LeishManios的发病机制中的潜在作用。

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