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首页> 美国卫生研究院文献>Antioxidants >Effects of Cardiovascular Resistance and Combined Exercise Training on Cardiovascular Performance and Blood Redox Parameters in Coronary Artery Disease Patients: An 8-Month Training-Detraining Randomized Intervention
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Effects of Cardiovascular Resistance and Combined Exercise Training on Cardiovascular Performance and Blood Redox Parameters in Coronary Artery Disease Patients: An 8-Month Training-Detraining Randomized Intervention

机译：心血管抗性和综合运动训练对冠状动脉疾病患者心血管性能和血氧化还原参数的影响：8个月的培训 - 破坏随机干预

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It is well-documented that chronic/regular exercise improves the cardiovascular function, decreases oxidative stress and enhances the antioxidant capacity in coronary artery disease (CAD) patients. However, there is insufficient evidence regarding the chronic effects of different types of training and detraining on cardiovascular function and the levels of oxidative stress and antioxidant status in these patients. Therefore, the present study aimed at investigating the effects of cardiovascular, resistance and combined exercise training followed by a three-month detraining period, on cardiovascular function, physical performance and blood redox status parameters in CAD patients. Sixty coronary artery disease patients were randomly assigned to either a cardiovascular training (CVT, N = 15), resistance training (RT, N = 11), combined cardiovascular and resistance training (CT, N = 16) or a control (C, N = 15) group. The training groups participated in an 8-month supervised training program (training three days/week) followed by a 3-month detraining period, while the control group participated only in measurements. Body composition, blood pressure, performance-related variables (aerobic capacity (VO2max), muscle strength, flexibility) and blood redox status-related parameters (thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), reduced glutathione (GSH), oxidized glutathione (GSSG), catalase activity (CAT), protein carbonyls (PC)) were assessed at the beginning of the study, after 4 and 8 months of training as well as following 1, 2 and 3 months of detraining (DT). CVT induced the most remarkable and pronounced alterations in blood pressure (~9% reduction in systolic blood pressure and ~5% in diastolic blood pressure) and redox status since it had a positive effect on all redox-related variables (ranging from 16 to 137%). RT and CT training affected positively some of the assessed (TAC, CAT and PC) redox-related variables. Performance-related variables retained the positive response of the training, whereas most of the redox status parameters, for all training groups, restored near to the pre-exercise values at the end of the DT period. These results indicate that exercise training has a significant effect on redox status of CAD. Three months of detraining is enough to abolish the exercise-induced beneficial effects on redox status, indicating that for a better antioxidant status, exercise must be a lifetime commitment.
机译：有条件地记录了慢性/常规运动改善心血管功能，降低氧化应激并增强冠状动脉疾病（CAD）患者的抗氧化能力。然而，有关不同类型训练的慢性效应和破坏心血管功能的慢性效应以及这些患者的氧化应激和抗氧化剂状态的慢性效应不足。因此，本研究旨在调查心血管，抗性和综合运动训练的影响，然后是CAD患者心血管功能，物理性能和血氧化还原状态参数的三个月下降期。将六十冠状动脉疾病患者随机分配给心血管训练（CVT，N = 15），阻力训练（RT，N = 11），组合心血管和抗性训练（CT，N = 16）或对照（C，N = 15）组。培训团体参加了8个月的监督培训计划（培训三天/周），然后是一个3个月的越来越多，而对照组仅参加了测量。身体成分，血压，性能相关变量（有氧能力（vo2max），肌肉力量，柔韧性）和血氧化还原状态相关参数（硫酰比尿酸反应物质（TBARS），总抗氧化容量（TAC），还原谷胱甘肽（GSH） ，在研究开始时评估氧化的谷胱甘肽（GSSG），过氧化氢酶活性（CAT），蛋白质羰基（PC）），经过4至8个月的培训，以及在促进（DT）之后的1,2和3个月后。 CVT诱导血压最显着和明显的改变（收缩压降低〜9％，舒张压血压〜5％）和氧化还原状态，因为它对所有与氧化还原相关的变量产生了积极影响（从16到137的范围。 ％）。 RT和CT培训积极影响一些评估（TAC，CAT和PC）氧化还原有关的变量。与培训的性能相关的变量保留了训练的积极响应，而所有训练组的大多数氧化还原状态参数靠近DT期结束时恢复到锻炼前值。这些结果表明，运动培训对CAD的氧化还原地位有显着影响。三个月的降价足以废除对氧化还原状态的运动诱导的有益效果，表明对于更好的抗氧化状态，运动必须是一生的承诺。

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