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首页> 外文期刊>European journal of cardiovascular prevention and rehabilitation: official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology >Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease.
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Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease.

机译：与经皮干预相比，定期运动训练可减少冠状动脉疾病患者的炎症标志物和心血管事件。

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BACKGROUND: Chronic vascular inflammation may trigger ischemic events whereas regular physical exercise training (ET) has shown to be cardioprotective in patients with coronary artery disease (CAD). We investigated the impact of 2 years regular ET versus percutaneous intervention (PCI) on chronic inflammation and cardiovascular events. METHODS AND RESULTS: A total of 101 male patients with stable CAD and an indication for revascularization were prospectively randomized to regular ET (n=51) or PCI with stentimplantation (n=50). High-sensitive C-reactive protein and interleukin-6, exercise capacity and ischemic endpoints were analyzed at baseline and after 2 years. At 2 years maximal oxygen consumption (VO2 max) increased by 10% in the ET group (23.3+/-0.6 to 25.7+/-1.0 ml O2/kg/min; P=0.0171 versus baseline) versus 7% in the PCI group (22.3+/-0.8 to 23.9+/-1.2 ml O2/kg/min; P=0.4248). In a subgroup of patients, high-sensitive C-reactive protein levels and interleukin-6 levels were significantly reduced after ET by 41 and 18%, respectively, whereas no relevant changes were observed in the PCI group. Event-free survival rates after 24 months were 78% (ET) versus 62% (PCI) (P=0.039). CONCLUSION: In patients with stable coronary artery disease, regular physical exercise is associated with a reduction of inflammatory markers and ischemic events.
机译：背景：慢性血管发炎可能会引发缺血性事件，而常规体育锻炼（ET）已显示对冠心病（CAD）患者具有心脏保护作用。我们调查了2年常规ET与经皮介入治疗（PCI）对慢性炎症和心血管事件的影响。方法和结果：总共101例男性CAD稳定且有血运重建指征的患者前瞻性随机分为常规ET（n = 51）或PCI联合支架置入术（n = 50）。在基线时和2年后分析高敏C反应蛋白和白细胞介素6，运动能力和缺血终点。在2年时，ET组的最大耗氧量（VO2 max）增加了10％（23.3 +/- 0.6至25.7 +/- 1.0 ml O2 / kg / min;相对于基线，P = 0.0171），而PCI组为7％ （22.3 +/- 0.8至23.9 +/- 1.2ml O 2 /kg/min;P＝0.4248）。在亚组患者中，ET后高敏感的C反应蛋白水平和白介素6水平分别显着降低了41％和18％，而在PCI组中未观察到相关变化。 24个月后无事件生存率分别为78％（ET）和62％（PCI）（P = 0.039）。结论：在患有稳定的冠状动脉疾病的患者中，定期进行体育锻炼可以减少炎症标志物和缺血事件。

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