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Glycated Hemoglobin and Methods for Its Point of Care Testing

机译：糖化血红蛋白及其护理测试点的方法

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摘要

Glycated hemoglobin (HbA1c) is a product of the spontaneous reaction between hemoglobin and elevated glucose levels in the blood. It is included among the so-called advanced glycation end products, of which is the most important for the clinical diagnosis of diabetes mellitus, and it can serve as an alternative to glycemia measurement. Compared to the diagnosis of diabetes mellitus by glycemia, the HbA1c level is less influenced by a short-term problem with diabetes compensation. Mass spectroscopy and chromatographic techniques are among the standard methods of HbA1c level measurement. Compared to glycemia measurement, there is lack of simple methods for diabetes mellitus diagnosis by means of the HbA1c assay using a point-of-care test. This review article is focused on the surveying of facts about HbA1c and its importance in diabetes mellitus diagnosis, and surveying standard methods and new methods suitable for the HbA1c assay under point-of-care conditions. Various bioassays and biosensors are mentioned and their specifications are discussed.
机译：糖化血红蛋白（HBA1C）是血红蛋白和血液中血糖水平升高的自发反应的产物。它包括在所谓的先进糖糖末端产品中，其中对糖尿病的临床诊断最重要，并且可以作为糖血症测量的替代品。与糖尿病糖尿病的诊断相比，HBA1C水平受糖尿病补偿的短期问题的影响较小。质谱和色谱技术是HBA1C水平测量的标准方法。与糖血症测量相比，缺乏使用护理点测试的HBA1C测定缺乏糖尿病患者的简单方法。本篇综述文章专注于调查HBA1C的事实及其在糖尿病诊断中的重要性，以及调查适用于在护理点条件下的HBA1C测定的标准方法和新方法。可列举出各种生物测定和生物传感器，并讨论其规格。

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