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首页> 美国卫生研究院文献>Healthcare >Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
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Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia

机译：在Covid-19锁定期间献血者中缺乏对SARS-COV-2的抗体：沙特阿拉伯的研究

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In response to the coronavirus disease 2019 (COVID-19), Saudi Arabia have imposed timely restrictions to minimize the infection spread, lower the risk for vulnerable groups, and reduce the pressure on healthcare services. The effectiveness of these measures has not been assessed comprehensively and, thereby, remains uncertain. Besides monitoring the number of COVID-19 cases diagnosed by molecular assays, the seroprevalence can serve as an indicator for the incidence rate among the general population. This study aimed to evaluate seroprevalence status of all healthy blood donors who attended one of the main largest hospital located in the western region of Saudi Arabia from 1 January to 31 May 2020. The study period covered two months prior to reporting the first COVID-19 case in the country on 2 March 2020. Importantly, it covered the period when “lock-down type” measures have been enforced. Samples were subjected to in-house enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and microneutralization (MN). The sero statuses of all samples were confirmed negative, demonstrating the lack of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among blood donors during COVID-19 lockdown period. This study supports the hypothesis that COVID-19 restrictions have potential for limiting the extent of the infection.
机译：为了应对2019年冠状病毒疾病（Covid-19），沙特阿拉伯造成了及时限制，以尽量减少感染传播，降低弱势群体的风险，降低医疗服务的压力。这些措施的有效性尚未全面评估，从而仍然不确定。除了监测分子测定诊断的Covid-19病例的数量之外，Seroprengencess可以用作普通人群中发病率的指标。本研究旨在评估从1月1日1日月到2020年5月1日至5月31日，在沙特阿拉伯西部地区出席的所有健康献血者的血清升迁状况。在报告第一个Covid-19之前，研究期限涵盖了两个月2020年3月2日在该国的案例。重要的是，它涵盖了“锁定类型”措施所强制执行的时期。将样品进行内部酶联免疫吸附测定（ELISA），化学发光免疫测定（CLIA）和微生力和均匀（MN）。所有样品的血清状态确认为阴性，证明在Covid-19锁定期间血液供体中缺乏对严重急性呼吸综合征冠状病毒2（SARS-COV-2）的抗体。本研究支持Covid-19限制具有限制感染程度的可能性的假设。

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