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UPLC-PDA-Q Exactive Orbitrap-MS profiling of the lipophilic compounds product isolated from

机译：UPLC-PDA-Q离防脂肪酸化合物产品的剖面性分离

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摘要

The lipophilic compounds product (LCP), which was isolated and purified from Eucalyptus viminalis plants, has shown earlier broad antimicrobial and anti-inflammatory activities. To study secondary compounds responsible for the pharmacological activities, chemical composition of the LCP was studied with application of ultra-performance liquid chromatography combined with photodiode array detector and high-resolution Q Exactive Orbitrap mass spectrometer (UPLC-PDA-HRMS/MS). There were found thirty two compounds: twenty phloroglucinol derivatives (isopentyl diformyl phloroglucinol, macrocarpals, sideroxylonals, etc.), eight ursane type triterpenoids (loxanic acid, dehydroursolic acid lactone, dehydroursolic acid lactone acetate, two isomers of p-coumaroyl-dehydroursolic acid lactone and two isomers of feruloyl-dehydroursolic acid lactone), sequiterpenoid (S)-β-macrocarpene and three unknown phenolics. The major compounds of the LCP were pharmacologically active macrocarpals A and B, dehydroursolic acid lactone and its derivatives. It is supposed that previously discovered antimicrobial and anti-inflammatory activities of the LCP is due to the high contents of these secondary compounds.
机译：从桉树Viminalis植物中分离和纯化的亲脂性化合物产物（LCP）表明了早期的抗微生物和抗炎活性。为了研究负责药理学活性的二次化合物，研究了LCP的化学组成，采用超级性能液相色谱法与光电二极管阵列检测器和高分辨率Q辐射锻体质谱仪（UPLC-PDA-HRMS / MS）合并。发现了三十两种化合物：二十甘油蛋白衍生物（异戊烯氨基甲苯酚，宏观，纵向氧化丙酮等），八核酸型三萜类化合物（洛甲酸，脱氢糖酸内酯，脱氢硅酸内酯乙酸酯，P-COUMAROYL-DEHYDROLIC酸内酯的两种异构体与二磺酰脱氢硅酸内酯的两种异构体），螯合萜（S）-β-宏羧和三种未知的酚类。 LCP的主要化合物是药理学活性宏观A和B，脱氢硅酸内酯及其衍生物。假设以前发现的LCP的抗微生物和抗炎活性是由于这些二级化合物的高含量。

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