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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective Randomized Controlled Trial
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Quality of Recovery after Laparoscopic Cholecystectomy Following Neuromuscular Blockade Reversal with Neostigmine or Sugammadex: A Prospective Randomized Controlled Trial

机译：腹腔镜胆囊切除术后神经肌肉阻滞逆转后腹腔镜胆囊切除术后的质量逆转：鉴于预期随机对照试验

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The risk of neuromuscular blockade is certainly minimized by sugammadex in combination with monitoring. However, the effect of sugammadex-aided recovery on patients’ satisfaction is unclear. This study compared the Quality of Recovery (QoR)-15 score, which is a patient-reported outcome, in patients undergoing laparoscopic cholecystectomy. Eighty patients were randomly assigned to the neostigmine or sugammadex groups. At the end of surgery, neostigmine or sugammadex was administered, and tracheal extubation was performed after confirmation of a train of four ratio ≥ 0.9. The QoR-15 questionnaire was administered at 1 day before surgery and on post-operative days (POD) 1 and 2. The primary outcome was the QoR-15 score on POD 1. The secondary outcomes were the QoR-15 score on POD 2, modified Aldrete score, length of post-anesthetic care unit stay, post-operative pain, administration of anti-emetics, urinary retention, and length of hospital stay. No significant differences were found in QoR-15 scores on POD 1 (94.4 vs. 95.5, p = 0.87) or 2 (116.3 vs. 122, p = 0.33). Secondary outcomes were also comparable, with the exception of urinary retention (15.8% neostigmine vs. 2.6% sugammadex, p = 0.04). This study demonstrated that the quality of recovery was comparable between the neostigmine and sugammadex groups when reversal and tracheal extubation were performed in accordance with the current guidelines.
机译：通过Sugammadex与监测结合时，神经肌肉阻滞的风险肯定最小化。然而，诉诸于患者满意度的辛烷义的疗效尚不清楚。本研究比较了腹腔镜胆囊切除术患者的恢复质量（QOR）-15分数，这是患者报告的结果。将八十名患者随机分配给Neostigmine或Sugammadex组。在手术结束时，施用Neostigmine或Sugammadex，并在确认四个比例≥0.9的火车后进行气管拔管。 QOR-15调查问卷在手术前的1天和操作后的日期（POD）1和2. POD 1上的QOR-15分数。次级结果是POD 2的QOR-15得分，改进的糖糖度得分，麻醉后护理单位的长度，术后疼痛，抗媒体管理，尿潴留和住院时间的长度。在POD 1（94.4与95.5，P = 0.87）或2（116.3与122，P = 0.33）中，在QOR-15分数中没有发现显着差异。二次结果也是可比的，除尿潴留外（15.8％Neostigmine对2.6％Sugammadex，P = 0.04）。本研究表明，当逆转和气管拔管时，Neostigmine和Sugammadex群之间的恢复质量是可比的。

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