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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Imbalance in the Levels of Angiogenic Factors in Patients with Acute and Chronic Central Serous Chorioretinopathy
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Imbalance in the Levels of Angiogenic Factors in Patients with Acute and Chronic Central Serous Chorioretinopathy

机译：急性和慢性中枢性浆液性胆小胰腺炎患者血管生成因子水平的不平衡

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Background: The pathogenesis of central serous chorioretinopathy (CSC) remains a subject of intensive research. We aimed to determine correlations between plasma levels of selected angiogenic factors and different forms of CSC. Methods: Eighty patients were enrolled in the study including 30 with a chronic form of CSC, 30 with acute CSC, and 20 controls. Presence of active CSC was determined by fluorescein angiography (FA), indocyanine green angiography (ICGA), and swept-source optical coherence tomography (SS-OCT). Plasma concentrations of angiopoietin-1, endostatin, fibroblast growth factor, placental growth factor (PlGF), platelet-derived growth factor (PDGF-AA), thrombospondin-2, vascular endothelial growth factor (VEGF), VEGF-D, and pigment epithelium–derived factor were measured, and the results were compared between groups. Additionally, mean choroidal thickness (CT) was measured in all patients. Results: Levels of angiopoietin-1 (p = 0.008), PlGF (p = 0.045), and PDGF-AA (p = 0.033) differed significantly between the three groups. Compared with the controls, VEGF (p = 0.024), PlGF (p = 0.013), and PDGF-AA (p = 0.012) were downregulated in the whole CSC group, specifically PDGF-AA (p = 0.002) in acute CSC and angiopoietin-1 (p = 0.007) in chronic CSC. An inverse correlation between mean CT and VEGF levels was noted in CSC patients (rho = −0.27, p = 0.044). Conclusions: Downregulated angiopoietin-1, VEGF, PDGF-AA, and PlGF levels may highlight the previously unknown role of the imbalanced levels of proangiogenic and antiangiogenic factors in the pathogenesis of CSC. Moreover, downregulated VEGF levels may suggest that choroidal neovascularization in CSC is associated with arteriogenesis rather than angiogenesis.
机译：背景：中枢性浆液性胆管胰肿素病（CSC）的发病机制仍然是密集研究的主题。我们旨在确定所选择的血管生成因子和不同形式的CSC血浆水平之间的相关性。方法：八十名患者注册研究，包括30种慢性形式的CSC，30例，具有急性CSC和20种对照。通过荧光素血管造影（FA），吲哚菁绿色血管造影（ICGA）和扫描源光学相干断层扫描（SS-OCT）确定活性CSC的存在。血浆浓度的血管发成素-1，内抑素，成纤维细胞生长因子，胎盘生长因子（PLGF），血小板衍生的生长因子（PDGF-AA），血栓动素-2，血管内皮生长因子（VEGF），VEGF-D和颜料上皮测量了不停的因子，并在组之间比较结果。另外，在所有患者中测量平均脉络膜厚度（CT）。结果：血管发成素-1（P = 0.008），PLGF（P = 0.045）和PDGF-AA（P = 0.033）之间的水平显着不同。与对照相比，VEGF（P = 0.024），PLGF（P = 0.013）和PDGF-AA（P = 0.012）在整个CSC组中下调，特别是PDGF-AA（P = 0.002），在急性CSC和血管生成素中-1（p = 0.007）在慢性CSC中。在CSC患者中注意到平均CT和VEGF水平之间的反比相关性（RHO = -0.27，P = 0.044）。结论：下调血管血红素-1，VEGF，PDGF-AA和PLGF水平可突出常压和抗血管生成因子在CSC发病机制中的不平衡水平的先前未知作用。此外，下调的VEGF水平可能表明CSC中的脉络膜新生血管形成与动脉发生而不是血管生成。

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