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首页> 美国卫生研究院文献>Molecules >Tissue mRNA for S100A4 S100A6 S100A8 S100A9 S100A11 and S100P Proteins in Colorectal Neoplasia: A Pilot Study
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Tissue mRNA for S100A4 S100A6 S100A8 S100A9 S100A11 and S100P Proteins in Colorectal Neoplasia: A Pilot Study

机译：S100A4S100A6S100A8S100A9S100A11和S100P蛋白的组织mRNA在结肠直肠瘤周期：试验研究

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S100 proteins are involved in the pathogenesis of sporadic colorectal carcinoma through different mechanisms. The aim of our study was to assess tissue mRNA encoding S100 proteins in patients with non-advanced and advanced colorectal adenoma. Mucosal biopsies were taken from the caecum, transverse colon and rectum during diagnostic and/or therapeutic colonoscopy. Another biopsy was obtained from adenomatous tissue in the advanced adenoma group. The tissue mRNA for each S100 protein (S100A4, S100A6, S100A8, S100A9, S100A11 and S100P) was investigated. Eighteen biopsies were obtained from the healthy mucosa in controls and the non-advanced adenoma group (six individuals in each group) and thirty biopsies in the advanced adenoma group (ten patients). Nine biopsies were obtained from advanced adenoma tissue (9/10 patients). Significant differences in mRNA investigated in the healthy mucosa were identified between (1) controls and the advanced adenoma group for S100A6 (p = 0.012), (2) controls and the non-advanced adenoma group for S100A8 (p = 0.033) and (3) controls and the advanced adenoma group for S100A11 (p = 0.005). In the advanced adenoma group, differences between the healthy mucosa and adenomatous tissue were found in S100A6 (p = 0.002), S100A8 (p = 0.002), S100A9 (p = 0.021) and S100A11 (p = 0.029). Abnormal mRNA expression for different S100 proteins was identified in the pathological adenomatous tissue as well as in the morphologically normal large intestinal mucosa.
机译：S100蛋白通过不同的机制参与散发性结肠直肠癌的发病机制。我们的研究目的是评估编码非先进和晚期结肠直肠腺瘤的患者的组织mRNA编码S100蛋白。在诊断和/或治疗结肠镜检查期间从盲肠，横向结肠和直肠中取出粘膜活检。另一种活组织检查是从晚期腺瘤组中的腺瘤组织获得的。研究了每个S100蛋白的组织mRNA（S100A4，S100A6，S100A8，S100A9，S100A11和S100P）。从对照中的健康粘膜和非晚期腺瘤组（每组六个人）和晚期腺瘤组（十名患者）中有三十个活组织检查获得18个活组织检查。从晚期腺瘤组织（9/10患者）获得九项活检。在S100A6（P = 0.012），（2）对照组（P = 0.012），（2）对照组（P = 0.033）和非先进腺瘤组（P = 0.033）和（3 ）S100A11的对照和高级腺瘤组（P = 0.005）。在先进的腺瘤组中，S100A6（P = 0.002），S100A8（P = 0.002），S100A9（P = 0.021）和S100A11（P = 0.029）中发现了健康粘膜和腺瘤组织之间的差异。在病理腺瘤组织中鉴定出不同S100蛋白的异常mRNA表达以及形态正常的大肠粘膜。

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