• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Pharmaceutics >Conformal Coating of Powder by Initiated Chemical Vapor Deposition on Vibrating Substrate
【2h】

Conformal Coating of Powder by Initiated Chemical Vapor Deposition on Vibrating Substrate

机译：通过引发的振动基材的化学气相沉积对粉末的共形涂层

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Encapsulation of pharmaceutical powders within thin functional polymer films is a powerful and versatile method to modify drug release properties. Conformal coating over the complete surface of the particle via chemical vapor deposition techniques is a challenging task due to the compromised gas–solid contact. In this study, an initiated chemical vapor deposition reactor was adapted with speakers and vibration of particles was achieved by playing AC/DC’s song “Thunderstruck” to overcome the above-mentioned problem. To show the possibilities of this method, two types of powder of very different particle sizes were chosen, magnesium citrate (3–10 µm, cohesive powder) and aspirin (100–500 µm, good flowability), and coated with poly-ethylene-glycol-di-methacrylate. The release curve of coated magnesium citrate powder was retarded compared to uncoated powder. However, neither changing the thickness coating nor vibrating the powder during the deposition had influence on the release parameters, indicating, that cohesive powders cannot be coated conformally. The release of coated aspirin was as well retarded as compared to uncoated aspirin, especially in the case of the powder that vibrated during deposition. We attribute the enhancement of the retarded release to the formation of a conformal coating on the aspirin powder.
机译：薄官能聚合物膜内的药物粉末的封装是一种强大而通用的方法，可改变药物释放性能。通过化学气相沉积技术在颗粒的完整表面上的共形涂层是由于受损的气体固体接触而具有具有挑战性的任务。在该研究中，通过演奏AC / DC的歌曲“ThunderStruck”来实现引发的化学气相沉积反应器，并通过播放AC / DC的歌曲“雷氏道”来实现粒子的振动来克服上述问题。为了表明这种方法的可能性，选择了两种类型的粒度粉末，柠檬酸镁（3-10μm，粘性粉末）和阿司匹林（100-500μm，流动性良好），并涂有聚乙烯 - 乙二醇 - 二甲基丙烯酸酯。与未涂覆的粉末相比，将涂覆的柠檬酸镁粉末的释放曲线延迟。然而，在沉积期间，改变厚度涂层也没有振动粉末对释放参数的影响，表明，表示粘合剂不能共形地涂覆。与未涂覆的阿司匹林相比，涂覆的阿司匹林的释放与未涂覆的阿司匹林相比，特别是在沉积期间振动的粉末的情况下。我们将延迟释放的增强归因于在阿司匹林粉末上形成共形涂层。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号