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首页> 美国卫生研究院文献>Cancer Control : Journal of the Moffitt Cancer Center >The Change Trend of Cause of Death in Patients With Stage I Non-SmallCell Lung Cancer After Surgery in US: A Long-Term Follow-Up Study Based on SEERDatabase
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The Change Trend of Cause of Death in Patients With Stage I Non-SmallCell Lung Cancer After Surgery in US: A Long-Term Follow-Up Study Based on SEERDatabase

机译：舞台上患者死亡原因的变化趋势美国手术后细胞肺癌：基于SEER的长期后续研究数据库

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There are few studies on the cause of death in patients with stage I non-smallcell lung cancer after surgery. Our aim is to study the trend of cause of deathand risk factors affecting prognosis in the patients. We retrospectivelyreviewed patients in Surveillance, Epidemiology and End results database from2004 to 2015. The change trend between cause of death and follow-up time wasstudied by calculating the proportion of cause of death at different periods andanalyzing the cumulative risk. COX risk regression model was performed byunivariate and multivariate analyses for survival analysis. Finally, 23,652patients were enrolled. In the whole cohort, lung cancer accounted for 18.68% ofdeaths, followed by other causes (9.57%), heart disease (5.12%) and COPD(3.89%). With the increasing of follow-up time, the cumulative incidence of lungcancer was always the highest, but the growth rate in the late follow-up periodwas slower than that caused by heart disease and COPD. The proportion of deathdue to lung cancer decreased from 53.1%-73.1% in 0-30 months after follow-up to7.8%-41.4% in 90 months after follow-up, while the proportion of deaths due toheart disease and COPD increased. Age was an independent risk factor for lungcancer-, heart disease- and COPD-specific survival, while lobectomy resectionwas a protective factor, even in patients older than 70 years old. Inconclusion, during the follow-up period, lung cancer was still the main cause ofdeath, but the proportion of patients died of heart disease and COPD increasedgradually, especially in elderly. Furthermore, age was an important independentfactor affecting prognosis, particularly for heart disease- and COPD-relatedmortality. The application of wedge resection in elderly patients needs furtherexploration.
机译：关于我非小阶段死亡原因的研究手术后细胞肺癌。我们的目标是研究死亡原因的趋势影响患者预后的危险因素。我们回顾性从监测，流行病学和最终结果数据库中审查了患者2004年至2015年。死亡原因与随访时间之间的变化趋势是通过计算不同时期死亡原因的比例研究分析累积风险。 Cox风险回归模型是由生存分析的单变量和多变量分析。最后，23,652患者注册。在整个队列中，肺癌占18.68％死亡，其次是其他原因（9.57％），心脏病（5.12％）和COPD（3.89％）。随着随访时间的增加，肺的累积发病率癌症始终是最高的，但晚期随访期内的增长率慢于心脏病和COPD引起的慢。死亡比例由于肺癌在随访后0-30个月减少了53.1％-73.1％-73.1％在随访后90个月内7.8％-41.4％，而死亡的比例心脏病和COPD增加。年龄是肺的独立危险因素癌症 - ，心脏病和COPD特异性存活，而肺叶切除术甚至在70岁的患者中也是一种保护因素。在结论，在随访期间，肺癌仍然是主要原因死亡，但患者的比例死于心脏病和COPD逐渐，特别是老年人。此外，年龄是一个重要的独立影响预后的因素，特别是对心脏病和与COPD相关的死亡。楔形切除在老年患者中的应用进一步勘探。

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