The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis

机译：非酒精性脂肪肝疾病之谜：从非酒精性脂肪肝发展为非酒精性脂肪性肝炎

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摘要

Nonalcoholic fatty liver (NAFL) is an emerging global epidemic which progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis in a subset of subjects. Various reviews have focused on the etiology, epidemiology, pathogenesis and treatment of NAFLD. This review highlights specifically the triggers implicated in disease progression from NAFL to NASH. The integrating role of genes, dietary factors, innate immunity, cytokines and gut microbiome have been discussed.

机译：非酒精性脂肪肝（NAFL）是一种新兴的全球流行病，在部分受试者中发展为非酒精性脂肪性肝炎（NASH）和肝硬化。各种评论集中在NAFLD的病因，流行病学，发病机理和治疗上。这篇综述特别强调了与从NAFL到NASH的疾病进展有关的诱因。已经讨论了基因，饮食因素，先天免疫力，细胞因子和肠道微生物组的整合作用。

著录项

期刊名称 Journal of Clinical and Experimental Hepatology
作者
Mithun Sharma; Shasikala Mitnala; Ravi K. Vishnubhotla; Rathin Mukherjee; Duvvur N. Reddy; Padaki N. Rao;
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作者单位

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年(卷),期 2015(5),2
年度 2015
页码 147–158
总页数 12
原文格式 PDF
正文语种
中图分类外科学;
关键词
adiponectin cytokines gut microbiota lipotoxicity PNPLA3;

机译：脂联素;细胞因子;肠道菌群;脂毒性;PNPLA3;

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专利

1. Pathophysiological analysis of nonalcoholic fatty liver disease by evaluation of fatty liver changes and blood flow using xenon computed tomography: Can early-stage nonalcoholic steatohepatitis be distinguished from simple steatosis? [J] . Journal of gastroenterology . 2012,第11期

机译：通过使用氙气X线断层摄影术评估脂肪肝变化和血流，对非酒精性脂肪性肝病进行病理生理分析：能否将早期非酒精性脂肪性肝炎与单纯性脂肪变性区分开来？
2. Pathophysiological analysis of nonalcoholic fatty liver disease by evaluation of fatty liver changes and blood flow using xenon computed tomography: can early-stage nonalcoholic steatohepatitis be distinguished from simple steatosis? [J] . Ryuta Shigefuku, Hideaki Takahashi, Minoru Kobayashi, Journal of Gastroenterology . 2012,第11期

机译：通过使用氙气X线断层摄影术评估脂肪肝变化和血流，对非酒精性脂肪肝疾病进行病理生理分析：能否将早期非酒精性脂肪性肝炎与单纯性脂肪变性区分开来？
3. Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver [J] . The Journal of Immunology: Official Journal of the American Association of Immunologists . 2016,第1期

机译：从非酒精性脂肪肝发展为非酒精性脂肪性肝炎的特点是，肝脏中Th17细胞的频率较高，而外周血和肝脏中的Th17 / R调节性T细胞比例增加
4. A Deep Learning Approach for Classifying Nonalcoholic Steatohepatitis Patients from Nonalcoholic Fatty Liver Disease Patients Using Electronic Medical Records [C] . Pradyumna Byappanahalli Suresha, Yunlong Wang, Cao Xiao, Health Intelligence Workshop;Association for the Advancement of Artificial Intelligence Annual Conference . 2020

机译：使用电子医疗记录对非酒精性脂肪肝病患者的非酒精性脂肪性肝炎患者的深入学习方法
5. Role of Diet and Xenobiotics in the Progression of Nonalcoholic Fatty Liver Disease [D] . Li, Xilin. 2018

机译：饮食和异生物素在非酒精性脂肪肝疾病发展中的作用
6. Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Cirrhosis Confirmed by Liver Histology after 14 Years [O] . Miwa Kawanaka, Ken Nishino, Yumiko Morimoto, 2021

机译：14年后肝脏组织学证实非酒精性脂肪肝的进展肝脏脂肪肝肝硬化
7. The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis [O] . Mithun Sharma, Shasikala Mitnala, Ravi K. Vishnubhotla, 2015

机译：非酒精性脂肪肝疾病的谜语：非酒精性脂肪肝对非酒精性脂肪肝炎的进展

The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis

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