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首页> 美国卫生研究院文献>Hospital Pharmacy >Off-label Medications Use in the Eastern Province of Saudi Arabia:The Views of General Practitioners Pediatricians and OtherSpecialists
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Off-label Medications Use in the Eastern Province of Saudi Arabia:The Views of General Practitioners Pediatricians and OtherSpecialists

机译：在沙特阿拉伯东部地区使用的非标签药物：一般从业者儿科医生和其他人的意见专家

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Background: Off-label drug prescribing remains a major pediatrichealth concern worldwide. The lack of studies in this vulnerable populationcauses many practitioners to prescribe drugs outside their license. This studyaims to investigate and compare the current knowledge and views of generalpractitioners, pediatricians, and other specialists toward off-label pediatricprescribing. Methods: A descriptive, cross-sectional–based studyconducted on a random sample of physicians who work in three different hospitalsin the Eastern Province of Saudi Arabia. Results: Data wereobtained from three hospitals, comprising a total of 160 practitioners. Overall,more than half of the participated practitioners (54%) were familiar with thedefinition of off-label prescribing. Thirty percentage of participatedpractitioners agreed that more than 10% of their prescribed medicines tochildren were off-labeled. A majority of participants expressed concerns overthe efficacy (83%) and safety (92%) of off-label prescribing to children.Importantly, a noticeable proportion of the responders claimed that theysometimes observed an adverse drug reaction (n = 23; 20%) or treatment failure(n = 43; 37%) following off-label prescribing medicines to children. Only 46%participants have always informed the parents or guardian about the off-labelprescription of medications to their children. Conclusion: A Largenumber of physicians are familiar with the concept of off-label prescribing ofmedicines to children in the Eastern Province of Saudi Arabia. Safety andefficacy are the main concerns of prescribing such medications. Policies towardimproving pediatric clinical research and supporting the safety and efficacy ofthe drugs should be encouraged.
机译：背景：非标签药物规定仍然是一个主要的小儿科全世界健康问题。这种脆弱的人口缺乏研究导致许多从业者在许可证之外开出药物。这项研究旨在调查和比较当前的知识和一般意见从业者，儿科医生和其他专家走向标签小儿科处方。方法：基于描述，横截面的研究在三个不同的医院工作的医生随机样本上进行在沙特阿拉伯东部。结果：数据是从三家医院获得，共有160名从业者。总体，超过一半的参与的从业者（54％）熟悉了非标签规定的定义。三十个百分比的参与从业者同意超过10％的规定药物孩子们被禁止标记。大多数参与者都表示关切对儿童的偏出标签的疗效（83％）和安全性（92％）。重要的是，响应者的明显比例声称它们有时观察到不良药物反应（n = 23; 20％）或治疗失败（n = 43; 37％）在偏离标准的儿童后落下的药物。只有46％与会者总是向父母或监护人通知出标签药物的处方给孩子。结论：大医生人数熟悉非标签规定的概念沙特阿拉伯东部省儿童药物。安全和疗效是处方药物的主要问题。朝向的政策改善小儿临床研究并支持安全性和疗效应该鼓励药物。

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