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首页> 外文期刊>Hospital pharmacy. >Off-label Medications Use in the Eastern Province of Saudi Arabia: The Views of General Practitioners, Pediatricians, and Other Specialists
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Off-label Medications Use in the Eastern Province of Saudi Arabia: The Views of General Practitioners, Pediatricians, and Other Specialists

机译：在沙特阿拉伯东部省份的标签用药：全科学者，儿科医生和其他专家的意见

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Background: Off-label drug prescribing remains a major pediatric health concern worldwide. The lack of studies in this vulnerable population causes many practitioners to prescribe drugs outside their license. This study aims to investigate and compare the current knowledge and views of general practitioners, pediatricians, and other specialists toward off-label pediatric prescribing. Methods: A descriptive, cross-sectional-based study conducted on a random sample of physicians who work in three different hospitals in the Eastern Province of Saudi Arabia. Results: Data were obtained from three hospitals, comprising a total of 160 practitioners. Overall, more than half of the participated practitioners (54%) were familiar with the definition of off-label prescribing. Thirty percentage of participated practitioners agreed that more than 10% of their prescribed medicines to children were off-labeled. A majority of participants expressed concerns over the efficacy (83%) and safety (92%) of off-label prescribing to children. Importantly, a noticeable proportion of the responders claimed that they sometimes observed an adverse drug reaction (n = 23; 20%) or treatment failure (n = 43; 37%) following off-label prescribing medicines to children. Only 46% participants have always informed the parents or guardian about the off-label prescription of medications to their children. Conclusion: A Large number of physicians are familiar with the concept of off-label prescribing of medicines to children in the Eastern Province of Saudi Arabia. Safety and efficacy are the main concerns of prescribing such medications. Policies toward improving pediatric clinical research and supporting the safety and efficacy of the drugs should be encouraged.
机译：背景：非标签药物规定仍然是全世界主要的儿科健康问题。这种弱势群体的研究缺乏研究导致许多从业者在许可证之外开出药物。本研究旨在调查和比较普通从业者，儿科医生和其他专家对非标签儿科规定的知识和意见。方法：在沙特阿拉伯东部省三个不同医院工作的医生随机样本的基于描述性的横截面的研究。结果：从三家医院获得数据，共有160名从业者。总体而言，超过一半的参与的从业者（54％）熟悉非标签处方的定义。三十个百分比的参与的从业者同意，将超过10％的儿童所订的药物被禁止。大多数参与者对儿童处方的效果（83％）和安全性（92％）表示担忧。重要的是，响应者的明显比例声称它们有时会观察到在偏离儿童方案的药物后的药物反应（n = 23; 20％）或治疗衰竭（n = 43; 37％）。只有46％的参与者始终向父母或监护人通报给孩子的药物的非标签处方。结论：大量的医生熟悉了沙特阿拉伯东部省内儿童的概念。安全性和疗效是处方药物的主要问题。应鼓励改善儿科临床研究和支持药物安全性和疗效的政策。

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