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Determination of iodine detectability in different types of multiple-energy images for a photon-counting detector computed tomography system

机译:用于光子计数检测器计算机断层扫描系统的不同类型多能量图像中碘检测性的测定

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摘要

In addition to low-energy-threshold images (TLIs), photon-counting detector (PCD) computed tomography (CT) can generate virtual monoenergetic images (VMIs) and iodine maps. Our study sought to determine the image type that maximizes iodine detectability. Adult abdominal phantoms with iodine inserts of various concentrations and lesion sizes were scanned on a PCD-CT system. TLIs, VMIs at 50 keV, and iodine maps were generated, and iodine contrast-to-noise ratio (CNR) was measured. A channelized Hotelling observer was used to determine the area under the receiver-operating-characteristic curve (AUC) for iodine detectability. Iodine map CNR (0.57±0.42) was significantly higher (P<0.05) than for TLIs (0.46±0.26) and lower (P<0.001) than for VMIs at 50 keV (0.74±0.33) for 0.5 mgI/cc and a 35-cm phantom. For the same condition and an 8-mm lesion, iodine detectability from iodine maps (AUC=0.95±0.01) was significantly lower (P<0.001) than both TLIs (AUC=0.99±0.00) and VMIs (AUC=0.99±0.01). VMIs at 50 keV had similar detectability to TLIs and both outperformed iodine maps. The lowest detectable iodine concentration was 0.5 mgI/cc for an 8-mm lesion and 1.0 mgI/cc for a 4-mm lesion.
机译:除了低能量阈值图像(TLIS)之外,光子计数检测器(PCD)计算断层扫描(CT)可以生成虚拟单元图像(VMIS)和碘映射。我们的研究寻求确定最大化碘检测性的图像类型。在PCD-CT系统上扫描了具有各种浓度和病变尺寸的碘嵌段的成人腹部幽灵。 TLIS,VMIS处于50keV和碘图谱,测量碘对比度 - 噪声比(CNR)。用于确定接收器操作特征曲线(AUC)下的面积的通道化的热性观测器用于碘可检测性。碘映射CNR(0.57±0.42)显着高(P <0.05),比TLIS(0.46±0.26),低于50keV(0.74±0.33)的VMIs,0.5 mgi / cc和35的vmis(p <0.001) -cm phantom。对于相同的条件和8毫米病变,来自碘图谱的碘检测性(AUC = 0.95±0.01)显着降低(P <0.001),而不是TLIS(AUC = 0.99±0.00)和VMIS(AUC = 0.99±0.01) 。 50 kev的VMIS对TLIS的可检测性与TLIS相似,并且两种表现优于碘贴图。最低可检测的碘浓度为8mm病变为0.5mgi / cc,1.0mgi / cc为4mm病变。

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