• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Animal Science >Rumen-protected arginine in ewe lambs: effects on circulating serum amino acids and carotid artery hemodynamics
【2h】

Rumen-protected arginine in ewe lambs: effects on circulating serum amino acids and carotid artery hemodynamics

机译：欧盟羊羔保护的精氨酸：对循环血清氨基酸和颈动脉血流动力学的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sixty nonpregnant, nulliparous Rambouillet ewes (51 ± 1.4 kg initial body weight) were used in a completely randomized design to determine 1) if rumen-protected l-Arg (RP-ARG) supplementation would increase serum concentrations of amino acids resulting from Arg supplementation and metabolism, and decrease serum concentrations of amino acids that compete with Arg for transporters, 2) if RP-ARG supplementation would alter carotid artery hemodynamics, and 3) the most effective oral dose of RP-ARG to positively increase both circulating amino acids and improve peripheral tissue blood perfusion as measured by carotid hemodynamics. Ewes were penned individually in a temperature-controlled facility. Ewes were randomly assigned to one of four treatments: a control group that received no supplemental Arg (CON; 50 g of finely ground corn, only), or Arg-supplemented groups that received 90 (90), 180 (180), or 360 (360) mg RP-ARG·kg BW−1·d−1 mixed in 50 g of finely ground corn. Supplements were administered once daily for 14 d and fully consumed before the delivery of a total pelleted diet at 0630 and 1830 hours daily. Baseline and final blood samples were collected at days 0 (before treatment initiation) and 15, respectively. Doppler ultrasound was used to assess carotid arterial hemodynamics at 0600 hours on days 0 (before treatment initiation), 5, 8, 12, and 15. After 14 d of supplementation, ewes fed 180 had greater Arg (P = 0.05) and Orn (P = 0.05) and tended (P = 0.08) to have greater Asp in serum than ewes fed 90, and for these amino acids, ewes fed 180 were similar (P ≥ 0.16) compared with ewes fed 360. All supplemented ewes (90, 180, and 360) had a negative change (P = 0.02) from baseline when normalized to CON for the pulsatility and resistance indices, which indicate greater distal tissue blood perfusion and lower vascular resistance of blood flow, respectively. Additionally, there were quadratic responses for the pulsatility and resistance indices (P = 0.03 and 0.01, respectively) where ewes fed 180 had the greatest change from baseline when normalized to CON. Results indicate that Arg supplementation increased serum amino acid concentrations and improved peripheral tissue blood perfusion. The 180 mg·kg BW−1·d−1 RP-ARG dose was determined to be the optimal dose for nonpregnant, nulliparous Rambouillet ewes.
机译：六十不妊娠，在完全随机设计中使用零rambouillet ewes（51±1.4 kg初始体重），以确定1）如果瘤胃保护的l-arg（rp-arg）补充剂将增加由arg补充引起的血清浓度的氨基酸和新陈代谢，降低与转运蛋白的arg竞争的血清浓度，2）如果RP-Arg补充会改变颈动脉血流动力学，并且3）最有效的口服剂量的RP-Arg，以积极增加循环氨基酸和循环氨基酸和通过颈动脉血液动力学测量，改善外周组织血液灌注。母羊在温控设施中单独占用。将母羊随机分配到四种治疗中的一种：没有补充Arg（Con; 50g精细玉米，仅）或接受90（90），180（180）或360的Arg补充组的对照组（360）Mg RP-ARG·Kg BW-1·D-1混合在50克精细磨玉米中。每天给予补充剂14天，并在每天0630和1830小时递送总颗粒饮食之前完全消耗。在第0天（治疗开始之前）和15天收集基线和最终血液样品。多普勒超声用于在06 00小时内评估颈动脉血流动力学，在06 00小时（治疗开始之前），5,8,12和15.在补充14 d后，喂养180的母羊具有更高的arg（p = 0.05）和orn（ P = 0.05）并倾向于（P = 0.08）在血清中具有比喂养90的母母果酱更大的ASP，并且对于这些氨基酸，与喂养360的母羊相比，喂养180的EWES相似（p≥0.16）。所有补充母羊（90，当归一化以确认脉冲性和电阻指数时，从基线具有负变化（p = 0.02），这表明血流的更大远端组织血液灌注和较低的血管阻力。另外，对脉动性和电阻指数（P = 0.03和0.01）存在二次响应（分别为EWES馈送180的母线在标准化时从基线发生最大的变化。结果表明，Arg补充增加血清氨基酸浓度和改进的外周组织血液灌注。将180mg·kg Bw-1·d-1 rp-arg剂量确定为不孕妇的最佳剂量，无妊娠rambouillet母羊。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号