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Inflammation and Depression: A Nervous Plea for Psychiatry to Not Become Immune to Interpretation

机译：炎症和抑郁：精神病患者的神经抗拒不免疫解释

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The possibility that inflammation plays a causal role in major depression is an important claim in the emerging field of immunopsychiatry and has generated hope for new treatments. The aims of the present review are first to provide some historical background and to consider the evidence in favor of the claim that inflammation is causally involved in major depression. The second part discusses some of the possibilities allowed for by the use of broad ‘umbrella’ concepts, such as inflammation and stress, in terms of proposing new working hypotheses and potential mechanisms. The third part reviews proposed biomarkers of inflammation and depression and the final part addresses how elements discussed in the preceding sections are used in immunopsychiatry. The ‘umbrella’ concepts of inflammation and stress, as well as insufficiently-met criteria based inferences and reverse inferences are being used to some extent in immunopsychiatry. The field is therefore encouraged to specify concepts and constructs, as well as to consider potential alternative interpretations and explanations for findings obtained. The hope is that pointing out some of the potential problems will allow for a clearer picture of immunopsychiatry’s current strengths and limitations and help the field mature.
机译：炎症在重度抑郁症中起因果作用的可能性是新兴的免疫精神病学领域的重要主张，并为新疗法带来了希望。本综述的目的首先是提供一些历史背景，并考虑证据支持炎症是大抑郁症的因果关系。第二部分讨论了提出新的工作假设和潜在机制方面的广泛使用“伞”概念（例如炎症和压力）所允许的一些可能性。第三部分回顾了拟议的炎症和抑郁生物标志物，最后一部分讨论了在免疫精神病学中如何使用前面几节中讨论的元素。免疫精神病学在某种程度上使用了“伞”式的炎症和压力概念，以及基于标准和推论的标准不足。因此，鼓励该领域指定概念和构造，并考虑可能的替代解释和解释。希望指出一些潜在问题将使免疫精神病学目前的优势和局限性更加清晰，并有助于该领域的成熟。

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