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首页> 美国卫生研究院文献>Poultry Science >Organic cranberry pomace and its ethanolic extractives as feed supplement in broiler: impacts on serum Ig titers liver and bursal immunity
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Organic cranberry pomace and its ethanolic extractives as feed supplement in broiler: impacts on serum Ig titers liver and bursal immunity

机译：有机蔓越莓渣及其乙醇提取物作为肉鸡的饲料补充剂：对血清Ig滴度肝脏和Bursal免疫的影响

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With the pressure to reduce antibiotics use in poultry production, cost-effective alternative products need to be developed to enhance the bird's immunity. The present study evaluated the efficacy of cranberry fruit by-products to modulate immunity in broiler chickens. Broiler Cobb 500 chicks were fed a control basal diet, basal diet supplemented with bacitracin (BACI, 55 ppm), cranberry pomace at 1% and 2% (CP2), or cranberry pomace ethanolic extract at 150 and 300 ppm (COH300) for 30 d. Blood sera were analyzed at days 21 and 28 of age for Ig levels by ELISA. The innate and adaptive immune-related gene expression levels in the liver and bursa of Fabricius were investigated at 21 d of age by quantitative polymerase chain reaction arrays. At day 21, the highest IgY level was found in the blood serum of the CP2-fed birds. In the liver, 13 of the 22 differentially expressed genes were downregulated across all treatments compared with the control. Expression of genes belonging to innate immunity such as caspase 1 apoptosis–related cysteine peptidase, chemokine receptor 5, interferon gamma, myeloid differentiation primary response gene 88, and Toll-like receptor 3 were significantly downregulated mainly in BACI- and COH300-fed birds. In the bursa, 5 of 9 genes associated with the innate immunity were differentially expressed. The expression of anti-inflammatory IL-10 gene was upregulated in all treatment groups in bursa compared with the control. The expression of transferrin gene was significantly upregulated in livers of birds fed COH300 and in bursa of birds fed BACI, indicating feeding practices and organ-dependant modulation of this gene in broiler. Overall results of this study showed that cranberry product feed supplementation modulated the innate immune and suppressed proinflammatory cytokines in broilers, providing a platform for future investigations to develop berry products in poultry feeding.
机译：随着减少抗生素在家禽生产中使用的压力，需要开发成本效益的替代产品来提高鸟类的免疫力。本研究评估了蔓越莓果实副产物的功效调节肉鸡中的免疫力。肉鸡COBB 500雏鸡被喂养一种对照基础饮食，补充有甲硝酸（Baci，55ppm），1％和2％（CP2）的蔓越莓渣，或蔓越莓渣乙醇提取物，在150和300ppm（COH300）中，蔓越莓泡沫乙醇提取物30天。 ELISA的IG水平的第21天和第21天和28天分析了血血清。通过定量聚合酶链反应阵列在21d时在21 d中研究了肝脏和Bursa中的先天和适应性免疫相关基因表达水平。在第21天，在CP2喂养鸟类的血液中发现了最高的IgY水平。与对照相比，在所有治疗中，在所有治疗中下调22个差异表达基因的13个。属于先天免疫的基因的表达，例如Caspase1凋亡相关的半胱氨酸肽酶，趋化因子受体5，干扰素γ，髓样分化初级反应基因88和Toll样受体3主要是在Baci-and Coh300喂养的鸟类中显着下调。在Bursa中，差异表达了与先天免疫相关的9个基因中的5个。与对照相比，在Bursa的所有治疗组中令抗炎IL-10基因的表达。转铁蛋白基因的表达在喂养COH300的鸟类和喂养喂养BACI的鸟类的鸟类中显着上调，表明肉鸡中该基因的饲养实践和器官依赖性调节。本研究的总体结果表明，蔓越莓产品饲料补充剂调制肉鸡中的先天免疫和抑制的促炎细胞因子，为未来调查开发浆果饲料中的浆果产品的平台。

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