首页> 美国卫生研究院文献>Dermatology and Therapy >Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities

【2h】

Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities

机译：白细胞介素-17和白细胞介素-23：牛皮癣和相关合并症中的作用机制叙述

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

IL-23/IL-17–mediated effects on epidermal keratinocytes in psoriatic skin. Schematic showing the broad downstream effects of increased IL-23 and IL-17 signaling on various immune cell populations and keratinocyte biology. Regulated by IL-23, the primary effects of IL-17 on keratinocytes include the following: indirect induction of epidermal hyperplasia through cytokines such as IL-19; upregulation of the innate immune response and antimicrobial peptides; epidermal recruitment of leukocyte subsets through increased production of keratinocyte-derived chemokines; and transcription of multiple pro-inflammatory genes that act synergistically with tumor necrosis factor (TNF)-α to sustain the inflammatory events in psoriatic skin. PMN polymorphonuclear leukocyte; Th T helper.

机译：IL-23 / IL-17-介导对银屑病皮肤表皮角质蛋白酶的影响。展示在各种免疫细胞群和角质形成细胞生物学上增加IL-23和IL-17信号传导的宽下游效应。由IL-23调节，IL-17在角质形成细胞上的主要效果包括以下内容：通过细胞因子如IL-19的细胞因子间接诱导表皮增生;对先天免疫应答和抗微生物肽的上调;通过增加角质形成细胞趋化因子的产量，白细胞亚群的表皮募集;并转录多种炎症基因，其与肿瘤坏死因子（TNF）-α协同作用，以维持银屑病皮肤中的炎症事件。 PMN多相核白细胞;辅助者。

著录项

期刊名称 Dermatology and Therapy
作者
Alan Menter; Gerald G. Krueger; So Yeon Paek; Dario Kivelevitch; Iannis E. Adamopoulos; Richard G. Langley;
展开▼
作者单位

展开▼
年(卷),期 2021(11),2
年度 2021
页码 385–400
总页数 16
原文格式 PDF
正文语种
中图分类皮肤病学与性病学;
关键词

机译：组织;细胞因子;炎症;白细胞介素-17;白细胞介素-23;牛皮癣;

相似文献

外文文献
中文文献
专利

1. Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities [J] . Alan Menter, Gerald G. Krueger, So Yeon Paek, Dermatology and Therapy . 2021,第2期

机译：白细胞介素-17和白细胞介素-23：对牛皮癣和相关合并症的作用机制叙事综述
2. Systematic review of interleukin-12, interleukin-17, and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: Ustekinumab, briakinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab, and brodalumab [J] . TausendW., CenterforClinicalStudiesHouston, andTheUniversityofTexasMedicalSchoolatHoustonDepartmentofDermatology, Journal of cutaneous medicine and surgery . 2014,第3期

机译：白介素12，白介素17和白介素23途径抑制剂治疗中度至重度慢性斑块状牛皮癣的系统评价
3. Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits [J] . Lebwohl Mark G., Tanghetti Emil A., Stein Gold Linda, Dermatology and Therapy . 2021,第4期

机译：固定组合Halobetasol丙酸盐和塔拉替烯治疗牛皮癣：叙事审查行动机制和治疗福利机制
4. The Role of Tumour Necrosis Factor Alpha Inhibitors in Psychiatric Comorbidities in Psoriasis: Literature Review [C] . Botis C., Crisan M., Miclutia I. European Association of Psychosomatic Medicine., Annual Meeting. . 2014

机译：肿瘤坏死因子α抑制剂在牛皮癣精神病患者中的作用：文献综述
5. Elucidation of the mechanisms of interaction between bile acids and the interleukin-23/interleukin-17 axis during cholestasis. [D] . O'Brien, Kate Maureen. 2014

机译：阐明胆汁淤积过程中胆汁酸与白介素23 /白介素17轴之间的相互作用机制。
6. Assessing the relative efficacy of interleukin-17 and interleukin-23 targeted treatments for moderate-to-severe plaque psoriasis: A systematic review and network meta-analysis of PASI response [O] . Laura M. Sawyer, Kinga Malottki, Celia Sabry-Grant, 2012

机译：评估白介素17和白介素23靶向治疗中度至重度斑块状牛皮癣的相对疗效：PASI反应的系统评价和网络荟萃分析
7. Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities [O] . Alan Menter, Gerald G. Krueger, So Yeon Paek, 2021

机译：白细胞介素-17和白细胞介素-23：牛皮癣和相关合并症中的作用机制叙述

Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities

摘要

著录项

相似文献

相关主题

期刊订阅