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Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect

机译：胶原型矩阵对兔颅骨骨缺损组织再生的影响

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The cross-linking of collagen matrices (Cl_CM) may provide volume-stable enhanced defect regeneration when compared to non-cross-linked matrices (Ncl_CM). The aim of the present study was to investigate the bone forming potential of collagen matrices (CMs) and the effects of cross-linking CMs in a rabbit calvaria defect model. (1) Empty controls (n = 6), (2) Ncl_CM (n = 8), and (3) Cl_CM (n = 8) were selected to be observed for the healing in 10 mm critical-sized calvarial bone defects. The potential for the bone as well as the connective tissue formation were evaluated by micro-CT and histomorphometry at three months post-surgery. There were no statistically significant differences in terms of new bone volume in the defects between the groups. However, the Cl_CM induced significantly greater fibrous tissue regeneration (5.29 ± 1.57 mm2) when compared to the controls (3.51 ± 0.93 mm2) by histomorphometry. The remnants of collagen fibers with immune cells, including macrophages and giant cells, were occasionally observed in the Cl_CM group but not in the Ncl_CM group. In conclusion, the cross-linking of collagen did not influence the potential for bone formation. Nevertheless, Cl_CM might be advantageous for the maintenance of fibrous tissue volume without disturbing bone formation in the defects.
机译：与非交联矩阵（NCL_CM）相比，胶原矩阵（CL_CM）的交联可以提供体积稳定的增强缺陷再生。本研究的目的是研究胶原蛋白酶矩阵（CMS）的骨形成潜力以及交联CMS在兔Calvaria缺陷模型中的影响。 （1）空对照（n = 6），（2）NCL_CM（n = 8），并选择愈合为10mm临界大小的颅骨缺损的愈合来观察到（3）CL_CM（n = 8）。通过微型CT和组织形态学在手术后三个月评估骨骼以及结缔组织形成的可能性。在群体之间的缺陷中，新的骨体积方面没有统计学上显着差异。然而，与通过组织形态学的对照（3.51±0.93mm 2）相比，CL_CM诱导更大的纤维组织再生（5.29±1.57mm 2）。在CL_CM组中偶尔观察到具有免疫细胞的胶原纤维的残余物，包括巨噬细胞和巨细胞，但不在NCL_CM组中观察到。总之，胶原蛋白的交联不会影响骨形成的潜力。然而，CL_CM可能是有利于维持纤维组织体积而不会干扰缺陷中的骨形成。

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