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首页> 美国卫生研究院文献>Medicines >Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis
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Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

机译：γ-戊二酰转肽酶联合碳水化合物缺乏转移素的临床意义缺乏含酒精肝硬化患者过量饮酒的评估

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Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.
机译：背景：本研究旨在比较碳水化合物缺陷型转移素（CDT）和γ-谷氨酰胺转移酶（γ-GTP）的诊断性能，以评估这些生物标志物的单一和综合益处，用于检测酒精性患者患者慢性过量醇消耗肝硬化。方法：从酒精性肝硬化患者（饮酒组，n = 35;非重定组，n = 81）中，在血液样本中测定生物标志物。单独的预测精度单独，γ-GTP单独，以及它们对含酒精肝硬化的患者测定过量醇消费的组合。结果：血清总胆红素，丙氨酸氨基转移酶，天冬氨酸氨基转移酶，γ-GTP和碱性磷酸酶水平明显较高，饮用组在非重定组中血清白蛋白水平显着降低。仅与I％CDT或γ-GTP相比，％CDT和γ-GTP的组合仅显示更高的预测精度。 ％CDT和γ-GTP的组合单独表现出比γ-GTP更高的特异性。然而，就灵敏度而言，单个或组合标记之间没有发现显着差异。结论：％CDT和γ-GTP的组合被认为是酒精性肝硬化患者慢性过量醇消耗的有用生物标志物。

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