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首页> 美国卫生研究院文献>Journal of Cancer >Cervical Cancers Manifest a High Rate of Infection by a High-Risk Human Papilloma Virus Subtype but a Very Low Rate of Infection by a Low-Risk Subtype in the Guiyang District of China
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Cervical Cancers Manifest a High Rate of Infection by a High-Risk Human Papilloma Virus Subtype but a Very Low Rate of Infection by a Low-Risk Subtype in the Guiyang District of China

机译：宫颈癌在中国贵阳地区显示出高风险的人乳头瘤病毒亚型感染率高但低风险的亚型感染率低。

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The prevalence of infection by different genotypes of human papillomavirus (HPV) varies among different geographic areas. We studied the prevalence of infection by 21 HPV genotypes in cervical tissue specimens from 4213 women in the Guiyang district, that is located in the southwest of China and is dominated by minor ethnicities of Chinese, and 2074 cases in our cohort had pathological diagnosis available. The overall infection rate was 36.98%. Most (72.08%) infectors were positive for only one HPV subtype, with the remaining being cases infected by two or more subtypes. Infections by the HPV subtypes 16, 52 and 58 were the most prevalent, having rates of 34.66%, 16.03%% and 15.53%, respectively. The most common cervical lesions in HPV infections were genital warts, cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). Age and age at first sexual activity were independent risk factors for HPV infections that in turn cause certain cervical lesions. Intriguingly, while 94.90% of the CC patients were infected by oncogenically high-risk (HR) HPV subtypes, only 2.75% and 2.29% of these patients were infected by oncogenically low-risk (LR) subtypes or other-subtypes with their oncogenicity unclear. The rates of infection by LR-HPVs and other-HPVs were also low, being 4.63% and 6.76%, respectively, in the patients with CIN that is a precursor lesion of CC, lower than the 8.54% and 18.20%, respectively, in the women without a cervical lesion. Our data provides an important foundation for prevention, diagnosis and treatment of HPV infection in Guiyang district and suggests that development of vaccines for prevention and treatment of CC in this area should first target the HPV subtypes 16, 52 and 58, but not subtype 18 as for many other places. It deserves study whether infections by certain LR-HPVs and other-HPVs may serve as attenuated live vaccines for prevention of CC.
机译：在不同的地理区域内，不同基因型的人乳头瘤病毒（HPV）感染的流行程度有所不同。我们研究了来自21位HPV基因型在贵阳地区4213名妇女的宫颈组织标本中的感染率，该地区位于中国西南部，以华裔为主要人群，我们队列中的2074例可以进行病理诊断。总体感染率为36.98％。大多数（72.08％）感染者仅对一种HPV亚型呈阳性，其余为被两种或两种以上亚型感染的病例。 HPV亚型16、52和58的感染率最高，分别为34.66％，16.03 %%和15.53％。 HPV感染中最常见的宫颈病变是尖锐湿疣，宫颈癌（CC）和宫颈上皮内瘤变（CIN）。初次性行为的年龄和年龄是HPV感染的独立危险因素，而HPV感染又引起某些宫颈病变。有趣的是，虽然94.90％的CC患者被致癌高危（HR）HPV亚型感染，但这些患者中仅2.75％和2.29％被致癌低危（LR）亚型或其他亚型感染，其致癌性尚不清楚。 LR-HPV和其他HPV的感染率也很低，在CC的前病变CIN患者中，分别为4.63％和6.76％，低于分别为8.54％和18.20％的CIN患者。没有宫颈病变的妇女。我们的数据为贵阳地区HPV感染的预防，诊断和治疗提供了重要基础，并建议在该地区开发预防和治疗CC的疫苗应首先针对HPV亚型16、52和58，而不针对18亚型。在许多其他地方。某些LR-HPV和其他HPV的感染是否可以作为减毒活疫苗预防CC的研究值得研究。

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