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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography
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Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography

机译：高效液相色谱-微波集成萃取-浸出（MIEL）法快速测定绿色金鸡纳喹生物碱

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摘要

Quinas contains several compounds, such as quinoline alkaloids, principally quinine, quinidine, cinchonine and cichonidine. Identified from barks of Cinchona, quinine is still commonly used to treat human malaria. Microwave-Integrated Extraction and Leaching (MIEL) is proposed for the extraction of quinoline alkaloids from bark of Cinchona succirubra. The process is performed in four steps, which ensures complete, rapid and accurate extraction of the samples. Optimal conditions for extraction were obtained using a response surface methodology reached from a central composite design. The MIEL extraction has been compared with a conventional technique soxhlet extraction. The extracts of quinoline alkaloids from C. succirubra obtained by these two different methods were compared by HPLC. The extracts obtained by MIEL in 32 min were quantitatively (yield) and qualitatively (quinine, quinidine, cinchonine, cinchonidine) similar to those obtained by conventional Soxhlet extraction in 3 hours. MIEL is a green technology that serves as a good alternative for the extraction of Cinchona alkaloids.
机译：藜麦含有几种化合物，例如喹啉生物碱，主要是奎宁，奎尼丁，辛可宁和噻吩啶。从金鸡纳的树皮中鉴定出来的奎宁仍常用于治疗人类疟疾。有人提出用微波综合萃取浸出法从金鸡纳树皮中提取喹啉生物碱。该过程分四个步骤执行，以确保完整，快速和准确地提取样品。提取的最佳条件是使用从中央复合设计获得的响应面方法获得的。 MIEL提取已与常规技术索氏提取进行了比较。通过HPLC比较了通过这两种不同方法获得的来自丁香假单胞菌的喹啉生物碱提取物。通过MIEL在32分钟内获得的提取物的定量（收率）和定性（奎宁，奎尼丁，辛可宁，辛可尼定）与传统的索氏提取法在3小时内获得的提取物相似。 MIEL是一种绿色技术，可作为提取金鸡纳生物碱的良好选择。

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