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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging
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NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

机译：NutrimiRAging：通过营养微观管理营养传感途径促进健康老龄化

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Current sociodemographic predictions point to a demographic shift in developed and developing countries that will result in an unprecedented increase of the elderly population. This will be accompanied by an increase in age-related conditions that will strongly impair human health and quality of life. For this reason, aging is a major concern worldwide. Healthy aging depends on a combination of individual genetic factors and external environmental factors. Diet has been proved to be a powerful tool to modulate aging and caloric restriction has emerged as a valuable intervention in this regard. However, many questions about how a controlled caloric restriction intervention affects aging-related processes are still unanswered. Nutrient sensing pathways become deregulated with age and lose effectiveness with age. These pathways are a link between diet and aging. Thus, fully understanding this link is a mandatory step before bringing caloric restriction into practice. MicroRNAs have emerged as important regulators of cellular functions and can be modified by diet. Some microRNAs target genes encoding proteins and enzymes belonging to the nutrient sensing pathways and, therefore, may play key roles in the modulation of the aging process. In this review, we aimed to show the relationship between diet, nutrient sensing pathways and microRNAs in the context of aging.
机译：当前的社会人口学预测表明，发达国家和发展中国家的人口变化将导致老年人口的空前增长。这将伴随着与年龄有关的状况的增加，这将严重损害人类健康和生活质量。因此，老化是世界范围内的主要问题。健康的衰老取决于个体遗传因素和外部环境因素的结合。饮食已被证明是调节衰老的有力工具，并且热量限制已成为这方面的一种有价值的干预措施。然而，关于受控热量限制干预如何影响与衰老相关的过程的许多问题仍未得到解答。营养感应途径随着年龄的增长而放松，并且随着年龄的增长而失去效力。这些途径是饮食与衰老之间的联系。因此，在实践热量限制之前，充分了解此链接是必不可少的步骤。 MicroRNA已成为细胞功能的重要调节剂，可以通过饮食进行修饰。一些microRNA靶向编码属于营养物感应途径的蛋白质和酶的基因，因此可能在衰老过程的调节中起关键作用。在这篇综述中，我们旨在显示在衰老过程中饮食，营养物感应途径和microRNA之间的关系。

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