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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Comparative Transcriptome Analysis of the Pinewood Nematode Bursaphelenchus xylophilus Reveals the Molecular Mechanism Underlying Its Defense Response to Host-Derived α-pinene
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Comparative Transcriptome Analysis of the Pinewood Nematode Bursaphelenchus xylophilus Reveals the Molecular Mechanism Underlying Its Defense Response to Host-Derived α-pinene

机译：松材线虫Bursaphelenchus xylophilus的比较转录组分析揭示了其对宿主衍生的α-pine烯的防御反应的分子机制。

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摘要

Bursaphelenchus xylophilus is fatal to the pine trees around the world. The production of the pine tree secondary metabolite gradually increases in response to a B. xylophilus infestation, via a stress reaction mechanism(s). α-pinene is needed to combat the early stages of B. xylophilus infection and colonization, and to counter its pathogenesis. Therefore, research is needed to characterize the underlying molecular response(s) of B. xylophilus to resist α-pinene. We examined the effects of different concentrations of α-pinene on the mortality and reproduction rate of B. xylophilus in vitro. The molecular response by which B. xylophilus resists α-pinene was examined via comparative transcriptomics of the nematode. Notably, B. xylophilus genes involved in detoxification, transport, and receptor activities were differentially expressed in response to two different concentrations of α-pinene compared with control. Our results contribute to our understanding of the molecular mechanisms by which B. xylophilus responds to monoterpenes in general, and the pathogenesis of B. xylophilus.
机译：Bursaphelenchus xylophilus对全世界的松树是致命的。松树次生代谢产物的产生通过应激反应机制响应于木糖双歧杆菌侵染而逐渐增加。需要α-pine烯来对抗木糖双歧杆菌感染和定植的早期阶段，并应对其发病机理。因此，需要研究来表征木糖双歧杆菌抵抗α-pine烯的潜在分子反应。我们检查了不同浓度的α-pine烯对体外木糖双歧杆菌的死亡率和繁殖率的影响。通过线虫的比较转录组学检查了木糖双歧杆菌抵抗α-pine烯的分子反应。值得注意的是，与对照相比，响应于两种不同浓度的α-pine烯，参与解毒，转运和受体活性的木糖双歧杆菌基因差异表达。我们的结果有助于我们了解一般而言，木糖双歧杆菌对单萜有反应的分子机制，以及木糖双歧杆菌的发病机理。

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