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Efficacy of perampanel in a patient with epilepsia partialis continua

机译:持续性部分癫痫患者中perampanel的疗效

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摘要

Perampanel is the first-in-class selective and noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist. It is authorized in the U.S. and Europe as an add-on antiepileptic drug for partial-onset seizures, and for primary generalized tonic–clonic seizures. Single reports have also indicated a potential efficacy for myoclonic jerks. Here, we report a patient whose drug-resistant epilepsia partialis continua completely resolved after adding perampanel. She has remained seizure-free in an eighteen-month follow-up period. Epilepsia partialis continua reemerged transiently after perampanel was temporarily discontinued, with no recurrence after its reintroduction. Therefore, this effect was reproducible, and suggests that it might be worth trying perampanel in similar settings.
机译:Perampanel是同类中第一个选择性和非竞争性的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体拮抗剂。在美国和欧洲,它被批准作为抗癫痫药的附加药物,用于部分发作和原发性全身性强直-阵挛性发作。单一报告也表明了对肌阵挛性抽搐的潜在疗效。在此,我们报道了一名患者,在加入perampanel后其耐药性癫痫局部持续性完全消失。在十八个月的随访期内,她一直没有癫痫发作。暂时停用perampanel后,部分癫痫持续持续出现,重新引入后无复发。因此,这种效果是可重现的,并建议在相似的环境中尝试使用perampanel是值得的。

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