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首页> 美国卫生研究院文献>Indian Journal of Virology >Molecular epidemiology of rabies virus circulating in domestic animals in India
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Molecular epidemiology of rabies virus circulating in domestic animals in India

机译：印度家畜中流行的狂犬病毒分子流行病学

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摘要

Rabies is a neglected viral zoonotic disease affecting humans, domestic and wild animals and is endemic in most parts of the India. Dog mediated rabies is more predominant than other forms of rabies and molecular epidemiology is poorly understood in both reservoir and susceptible hosts. In the present study, a total of 140 rabies suspected brain samples from different species of animals from different geographical regions of India were used. The samples were parallelly tested by direct fluorescent antibody test, reverse transcriptase PCR and real-time PCR. Thirty positive samples were subjected for partial nucleoprotein gene sequencing and phylogenetic analysis. On sequence and phylogenetic analysis, it was observed that all Indian rabies viruses belonged to classical rabies virus of genotype 1 of Lyssavirus and formed two distinct groups. The majority of isolates were in group-1 and are closely related to arctic/arctic like lineage, whereas group–II isolated are closely related to cosmopolitan lineage. These results indicated there is simultaneous existence of two distinct lineages of rabies viruses in Indian subcontinent. Further whole genome studies are needed for better understanding of molecular epidemiology of rabies virus circulating in animals for control and prevention of rabies in India.Electronic supplementary materialThe online version of this article (10.1007/s13337-018-0478-9) contains supplementary material, which is available to authorized users.
机译：狂犬病是一种被忽略的病毒性人畜共患病，影响人类，家畜和野生动物，在印度大部分地区是地方性流行病。狗介导的狂犬病比其他形式的狂犬病更为主要，而且在宿主和易感宿主中对分子流行病学的了解也很少。在本研究中，总共使用了来自印度不同地理区域的140种狂犬病可疑脑样本。通过直接荧光抗体测试，逆转录酶PCR和实时PCR对样品进行平行测试。对三十个阳性样品进行部分核蛋白基因测序和系统发育分析。通过序列和系统发育分析，发现所有印度狂犬病病毒均属于狂犬病病毒基因型1的经典狂犬病病毒，并形成两个不同的群体。大多数分离株属于第1组，与北极/北极样谱系密切相关，而第II组分离株与国际大谱系密切相关。这些结果表明在印度次大陆上同时存在两种狂犬病病毒的不同谱系。需要进一步的全基因组研究以更好地了解在印度控制和预防狂犬病的动物狂犬病病毒分子流行病学。电子补充材料本文的在线版本（10.1007 / s13337-018-0478-9）包含补充材料，可供授权用户使用。

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