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Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys

机译：静脉输注或口服给予小鼠，兔子和猴子后ST-246®的安全性和药代动力学比较

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BackgroundST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (IV) formulation may be required for some hospitalized patients who are unable to take oral medication. An IV formulation has been evaluated in three species previously used in evaluation of both efficacy and toxicology of the oral formulation.

机译：背景技术ST-246®是在临床开发中用于治疗正痘病毒感染的抗病毒，口服生物可利用的小分子。对于某些无法服用口服药物的住院患者，可能需要静脉注射（IV）制剂。已经在先前用于评估口服制剂的功效和毒理学的三种物种中评估了IV制剂。

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期刊名称 PLoS Clinical Trials
作者
Yali Chen; Adams Amantana; Shanthakumar R. Tyavanagimatt; Daniela Zima; X. Steven Yan; Gopi Kasi; Morgan Weeks; Melialani A. Stone; William C. Weimers; Peter Samuel; Ying Tan; Kevin F. Jones; Daniel R. Lee; Shirley S. Kickner; Bradley M. Saville; Martin Lauzon; Alan McIntyre; Kady M. Honeychurch; Robert Jordan; Dennis E. Hruby; Janet M. Leeds;
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年(卷),期 2008(6),8
年度 2008
页码 e23237
总页数 10
原文格式 PDF
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1. 5-Fu静脉泵持续输注与口服希罗达治疗消化道肿瘤的安全性及疗效的观察 [J] . 中德临床肿瘤学杂志（英文版） . 2007,第005期
2. Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism. [J] . Chen Y, Cheng D, Tio C, Biopharmaceutics and Drug Disposition . 2008,第3期

机译：TDP4815在大鼠，兔，猴，狗和体外药物代谢中静脉内和口服给药后的药代动力学特性。
3. Pharmacokinetics of an everninomicin (SCH 27899) in mice, rats, rabbits, and cynomolgus monkeys following intravenous administration. [J] . Lin C, Gupta S, Loebenberg D, Antimicrobial agents and chemotherapy. . 2000,第4期

机译：静脉内给药后，在小鼠，大鼠，兔子和食蟹猴中使用了evernnomicin（SCH 27899）的药代动力学。
4. Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel Versus Oral Administration of Levodopa-Carbidopa Tablets in Japanese Subjects with Advanced Parkinson's Disease: Pharmacokinetics and Pilot Efficacy and Safety [J] . Othman Ahmed A., Chatamra Krai, Mohamed Mohamed-Eslam F., Clinical pharmacokinetics . 2015,第9期

机译：在患有晚期帕金森氏病的日本受试者中，左旋多巴-卡比多巴肠凝胶的空肠输液与左旋多巴-卡比多巴片的口服给药：药代动力学和先导功效与安全性
5. POSACONAZOLE PHARMACOKINETICS IN CATS AFTER ORAL AND IV ADMINISTRATION [C] . Dianne Mawby, Leanne Fowler, Mark Papich, Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：口服和IV管理后猫的posaconazole药代动力学
6. Pharmacokinetics of cimetidine in plasma and skin following IV-infusion administration in a rabbit model. [D] . Pandya, Ruchita. 2009

机译：西咪替丁在兔子模型中静脉输注后在血浆和皮肤中的药代动力学。
7. Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50 100 and 200 Milligrams) and Oral Administrations (100 200 and 400 Milligrams) of Its Prodrug BAL8557 in Healthy Volunteers [O] . Anne Schmitt-Hoffmann, Brigitte Roos, Markus Heep, 2006

机译：在健康志愿者中静脉注射（50、100和200毫克）和口服（100、200和400毫克）其前药BAL8557后新型广谱抗真菌三唑BAL4815的单剂量药代动力学和安全性
8. Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys [O] . Chen, Yali, Amantana, Adams, Tyavanagimatt, Shanthakumar R., 2011

机译：静脉输注或口服给予小鼠，兔子和猴子后ST-246®的安全性和药代动力学比较
9. Acute and Repeated Dose Toxicity Studies on Nsc 94100 Following Daily Oral Administration to Dogs and Monkeys and Acute Toxicity Following Oral Administration to Mice and Monkeys [R] . Rakieten, N., Schein, P. S., Davis, R. D. 1967

机译：Nsc 94100的急性和重复剂量毒性研究对狗和猴进行每日口服给药后口服给予小鼠和猴子的急性毒性

Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys

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