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Viral Reservoirs in Lymph Nodes of FIV-Infected Progressor and Long-Term Non-Progressor Cats during the Asymptomatic Phase

机译：无症状期感染FIV的进展性和长期非进展性猫的淋巴结中的病毒库

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BackgroundExamination of a cohort of cats experimentally infected with feline immunodeficiency virus (FIV) for 5.75 years revealed detectable proviral DNA in peripheral blood mononuclear cells (PBMCs) harvested during the asymptomatic phase, undetectable plasma viral RNA (FIV gag), and rarely detectable cell-associated viral RNA. Despite apparent viral latency in peripheral CD4+ T cells, circulating CD4+ T cell numbers progressively declined in progressor animals. The aim of this study was to explore this dichotomy of peripheral blood viral latency in the face of progressive immunopathology. The viral replication status, cellular immunophenotypes, and histopathologic features were compared between popliteal lymph nodes (PLNs) and peripheral blood. Also, we identified and further characterized one of the FIV-infected cats identified as a long-term non-progressor (LTNP).

机译：背景对一组实验性感染猫免疫缺陷病毒（FIV）的猫进行了5.75年的检查，发现无症状阶段收集的外周血单个核细胞（PBMC）中可检测到原病毒DNA，血浆病毒RNA（FIV gag）不可检测，并且很少检测到细胞-相关病毒RNA。尽管外周CD4 + T细胞有明显的病毒潜伏期，但进展动物的循环CD4 + T细胞数量逐渐减少。这项研究的目的是探索面对渐进式免疫病理学时外周血病毒潜伏期的二分法。比较pop淋巴结（PLN）和外周血之间的病毒复制状态，细胞免疫表型和组织病理学特征。此外，我们鉴定并进一步鉴定了一只被FIV感染的猫，它们被鉴定为长期无进展（LTNP）。

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期刊名称 PLoS Clinical Trials
作者
C. D. Eckstrand; C. Hillman; A. L. Smith; E. E. Sparger; B. G. Murphy;
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年(卷),期 2011(11),1
年度 2011
页码 e0146285
总页数 18
原文格式 PDF
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1. The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study [J] . Hinta Meijerink, Agnes R Indrati, Reinout van Crevel, BMC Infectious Diseases . 2014,第1期

机译：一项横断面研究：与正常进展者相比，在感染了病毒的长期感染非HIV感染的长期非进展者中，CCR5表达CD4 + T淋巴细胞的数量更低
2. HIV long-term non-progressors elite controllers: an interplay between host, immune and viral factors [J] . Lopez-Galindez Cecilio Future Virology . 2019,第4期

机译：艾滋病毒长期非进展精英控制器：宿主，免疫和病毒因素之间的相互作用
3. Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor [J] . Leon Caly, Nitin K Saksena, Sabine C Piller, Retrovirology . 2008,第S1期

机译：来自艾滋病毒长期非进步者的Vpr的核输入和病毒掺入受损
4. Constant Drug Dose Leading Long-Term Non-Progressor for HIV-Infected Patients with RTI and PI [C] . Jinyoung Kim, Won Hee Kim, Han Byul Chung, IEEE Conference on Decision and Control . 2005

机译：持续的药物剂量为艾滋病毒感染患者的长期非进化器持久的RTI和PI
5. Central and Peripheral Reservoirs of Feline Immunodeficiency Virus During the Asymptomatic Phase. [D] . Eckstrand, Christina. 2016

机译：在无症状阶段的猫免疫缺陷病毒的中央和外围水库。
6. The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study [O] . Hinta Meijerink, Agnes R Indrati, Reinout van Crevel, 2014

机译：横断面研究：与正常进展者相比在HIV感染的长期无进展者中病毒控制的CCR5表达CD4 + T淋巴细胞的数量更低
7. Viral Reservoirs in Lymph Nodes of FIV-Infected Progressor and Long-Term Non-Progressor Cats during the Asymptomatic Phase. [O] . C D Eckstrand, C Hillman, A L Smith, 2016

机译：FIV感染的进展者和长期非进展者猫在无症状期的淋巴结中的病毒储库。

Viral Reservoirs in Lymph Nodes of FIV-Infected Progressor and Long-Term Non-Progressor Cats during the Asymptomatic Phase

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