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首页> 美国卫生研究院文献>Springer Open Choice >The application of a lateral flow immunographic assay to rapidly test for dexamethasone in commercial facial masks
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The application of a lateral flow immunographic assay to rapidly test for dexamethasone in commercial facial masks

机译：侧流免疫分析法在快速检测商用面膜中地塞米松中的应用

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摘要

Dexamethasone (DE) is a synthetic glucocorticoid that is frequently added to cosmetic products for its good short-term effects, especially in facial masks, but long-term use is hazardous to the health. The abuse of DE in whitening and acne cosmetic products is currently a serious problem in China. It is necessary to establish a rapid method of detecting illegal DE addition in cosmetics. In the present study, a monoclonal antibody (mAb) against DE, 2D5-3D12, was developed that displayed cross-reactivities of 124.5%, 38.8%, 6.7%, 0.9%, 1.1%, 1.82%, and 2.39% with prednisolone, betamethasone, prednisone, beclomethasone, hydrocortisone, triamcinolone, and flumetasone, respectively. A colloidal gold-based lateral flow immunographic assay based on mAb 2D5-3D12 was established and used to determine the DE contents of commercial facial masks. The indicator range of the immunographic assay for DE was 100–200 ng/mL, and the results were consistent with those afforded by LC-MS. This novel method provides the advantages of simple sample treatment, a user-friendly procedure, and rapid detection. Graphical abstract
机译：地塞米松（DE）是一种合成的糖皮质激素，由于其良好的短期效果（尤其是在面膜中），经常被添加到化妆品中，但是长期使用对健康有害。在美白和粉刺化妆品中滥用DE是目前中国的一个严重问题。有必要建立一种快速检测化妆品中非法添加DE的方法。在本研究中，开发了针对DE 2D5-3D12的单克隆抗体（mAb），与泼尼松龙的交叉反应性分别为124.5％，38.8％，6.7％，0.9％，1.1％，1.82％和2.39％，倍他米松，泼尼松，倍氯米松，氢化可的松，曲安西龙和氟美他松。建立了基于mAb 2D5-3D12的胶体金基侧向流式免疫分析方法，并用于确定商用面膜的DE含量。 DE免疫测定的指标范围为100–200 ng / mL，结果与LC-MS提供的结果一致。这种新颖的方法具有简单的样品处理，用户友好的程序以及快速检测的优点。 <！-fig ft0-> <！-fig @ position =“ position” anchor“ == f4-> <！-fig mode =” anchred“ f5-> <！-fig / graphic | fig / alternatives / graphic mode =“ anchored” m1-> <！-caption a7->图形摘要

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