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Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status ALK mRNA and protein levels

机译：神经母细胞瘤中的间变性淋巴瘤激酶（ALK）抑制剂反应与ALK突变状态ALK mRNA和蛋白水平高度相关

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BackgroundIn pediatric neuroblastoma (NBL), high anaplastic lymphoma kinase (ALK) levels appear to be correlated with an unfavorable prognosis, regardless of ALK mutation status. This suggests a therapeutic role for ALK inhibitors in NBL patients. We examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins and response to ALK inhibition in a large panel of both ALK mutated and wild type (WT) NBL cell lines.

机译：背景在小儿神经母细胞瘤（NBL）中，高变性间变性淋巴瘤激酶（ALK）水平似乎与不良预后相关，而与ALK突变状态无关。这表明ALK抑制剂在NBL患者中具有治疗作用。我们检查了ALK突变和野生型（WT）NBL细胞系的一大小组中ALK，磷酸化ALK（pALK）和下游信号蛋白水平与对ALK抑制的反应之间的相关性。

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期刊名称 Springer Open Choice
作者
Floor A. M. Duijkers; José Gaal; Jules P. P. Meijerink; Pieter Admiraal; Rob Pieters; Ronald R. de Krijger; Max M. van Noesel;
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作者单位

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年(卷),期 -1(34),5
年度 -1
页码 409–417
总页数 9
原文格式 PDF
正文语种
中图分类外科学;
关键词
ALK Kinase inhibitor Neuroblastoma PHOX2B TAE684;

机译：ALK;激酶抑制剂;神经母细胞瘤;PHOX2B;TAE684;

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专利

1. Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels. [J] . Floor A M Duijkers, José Gaal, Jules P P Meijerink, Cellular oncology . 2011,第5期

机译：神经母细胞瘤中的间变性淋巴瘤激酶（ALK）抑制剂反应与ALK突变状态，ALK mRNA和蛋白质水平高度相关。
2. Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma. [J] . Daria Zdzalik, Barbara Dymek, Paulina Grygielewicz, Journal of Cancer Research and Clinical Oncology . 2014,第4期

机译：ALK激酶结构域中的激活突变赋予NPM-ALK阳性间变性大细胞淋巴瘤中结构无关的ALK抑制剂耐药性。
3. Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma. [J] . Daria Zdzalik, Barbara Dymek, Paulina Grygielewicz, Journal of Cancer Research and Clinical Oncology . 2014,第4期

机译：碱酶结构域的激活突变在NPM-ALK阳性促进性大细胞淋巴瘤中对结构不相关的ALK抑制剂的抵抗力。
4. Characterization of Differentially Expressed Plasma Membrane Proteins Induced by NPM-ALK for Investigating Aberrant Signaling Pathways in ALK~(+) Anaplastic Large Cell Lymphoma [C] . Difei Sun, Fang Wu, Peng Wang, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：用于研究ALK〜（+）促进大细胞淋巴瘤的异常信号通路的NPM-ALK鉴定的差异表达血浆膜蛋白的表征
5. Pharmacology Profiles of ALK and FLT3 Kinase Inhibitors against Non-Small-Cell Lung Cancer Cells and Acute Myeloid Leukemia Cells with Cancer Driver Mutations [D] . 森政道 2019

机译：ALK和FLT3激酶抑制剂对非小细胞肺癌细胞和急性髓系白血病细胞的癌症驱动突变的药理作用
6. Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma [O] . Daria Zdzalik, Barbara Dymek, Paulina Grygielewicz, -1

机译：ALK激酶结构域中的激活突变赋予NPM-ALK阳性间变性大细胞淋巴瘤中结构无关的ALK抑制剂耐药
7. Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels [O] . Floor A. M. Duijkers, José Gaal, Jules P. P. Meijerink, 2011

机译：神经母细胞瘤中的间变性淋巴瘤激酶（ALK）抑制剂反应与ALK突变状态，ALK mRNA和蛋白水平高度相关

Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status ALK mRNA and protein levels

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