Dihydroetorphine-induced place preference was mediated by dopamine D_1 receptors in rats

Liu Zhong-Hua; Zhang Kai-Gao

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Dihydroetorphine-induced place preference was mediated by dopamine D_1 receptors in rats

机译：多巴胺D_1受体介导双氢吗啡碱诱导的位置偏爱

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AIM: To study the influence of dopamine (DA) receptor antagonists upon the rewarding property of dihydroetoryphine (DHE). METHODS: Conditioned place preference (CPP) paradigm was used to characterize the rewarding effect of DHE. DA receptor antagonists were injeted administered subcutaneously or peritoneally and microinjected into nucleus accumbens (NAcc). CONCLUSION: The D_1 (but not D_2) receptors in NAcc are crucial in the Mediation of the rewarding effect of DHE.

机译：目的：研究多巴胺（DA）受体拮抗剂对二氢埃托啡（DHE）的奖励作用的影响。方法：条件位置偏好（CPP）范式被用来描述DHE的奖励作用。皮下或腹膜注射DA受体拮抗剂并显微注射到伏隔核（NAcc）中。结论：NAcc中的D_1（而非D_2）受体在介导DHE的奖励作用中起着至关重要的作用。

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《Acta Pharmacologica Sinica》 |1999年第4期|p.381-384|共4页
作者
Liu Zhong-Hua; Zhang Kai-Gao;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
dihydroetorphine; dopamine D_1 receptors; dopamine D_2 receptors;

机译：二氢吗啡多巴胺D_1受体;多巴胺D_2受体;

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Dihydroetorphine-induced place preference was mediated by dopamine D_1 receptors in rats

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