Supraspinal D_2 receptor involved in antinociception induced by l-tetrahydropalmatine

Hu Jiang-Yuan; Jin Guo-Zhang

首页> 外文期刊>Acta Pharmacologica Sinica >Supraspinal D_2 receptor involved in antinociception induced by l-tetrahydropalmatine

【24h】

Supraspinal D_2 receptor involved in antinociception induced by l-tetrahydropalmatine

机译：Supraaspinal D_2受体参与l-四氢巴马汀诱导的抗伤害感受

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

AIM: To study the role of dopamine (DA) receptors in l-tetrahydropalmtine (l-THP)-induced antinocicep- tion. METHODS: The intraperitoneal (ip) and intrathecal (ith) injections were used to give the drugs. The tail-flick test was used to assess the nociceptive Threshold of rats. RESULTS: By ip injection. l-THP (10,20,40 mg·kg~-1) as well as D_2 receptor antagonist spiperone (1,2,3 mg·kg~-1) produced dose-dependent antinociaceptive effects on the nocicep- tion of rats, while D_2 receptor agonist quinpirole, D_1 receptor agonist SKF38393, and D_1 receptor antagonist Sch-23390 showed no antinociception.

机译：目的：研究多巴胺（DA）受体在l-四氢巴马汀（l-THP）诱导的止痛药中的作用。方法：腹膜内（ip）和鞘内（ith）注射用于给药。甩尾试验用于评估大鼠的伤害阈值。结果：通过ip注入。 l-THP（10,20,40 mg·kg〜-1）和D_2受体拮抗剂spiperone（1,2,3 mg·kg〜-1）对大鼠的结局产生剂量依赖性的抗伤害作用， D_2受体激动剂喹吡罗，D_1受体激动剂SKF38393和D_1受体拮抗剂Sch-23390均未显示伤害感受。

著录项

来源
《Acta Pharmacologica Sinica》 |1999年第8期|p.715-719|共5页
作者
Hu Jiang-Yuan; Jin Guo-Zhang;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
tetrahydropalmatine; dopamine receptors; quinpirole;

机译：四氢巴马汀多巴胺受体;喹吡罗;

相似文献

外文文献
中文文献
专利

1. Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model. [J] . Chung KM, Song DK, Huh SO, Neuropeptides: An International Journal . 2000,第3a4期

机译：在福尔马林疼痛模型中，脑室内施用的吗啡和β-内啡肽使上丘脑NMDA和非NMDA受体差异地参与了抗伤害感受的产生。
2. Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. [J] . Hamurtekin E, Bagdas D, Gurun MS Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2007,第2期

机译：脊髓上阿片样物质和GABA受体可能参与大鼠急性疼痛模型中CDP-胆碱诱导的抗伤害感受。
3. Possible involvement of mu(1)-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites [J] . Narita M., Imai S., Itou Y., Life sciences . 2002,第20期

机译：mu（1）-阿片受体可能参与了上脊髓和脊髓上的芬太尼或吗啡诱导的抗伤害感受
4. Nuclear progesterone receptor is involved in the LH-induced expression of Ptger4b, a prostaglandin E_2 receptor indispensable for ovulation of the medaka [C] . Hagiwara A., Ogiwar K., Katsu Y., International Congress of Comparative Endocrinology . 2014

机译：核孕酮受体参与LH诱导的PTING4B表达，前列腺素E_2受体对于麦卡卡的排卵是必不可少的
5. Stimulant effects of cocaine induce fra-2 and sigma(1) receptors in brain regions involved in addiction and reward: Evidence from behavioral, gene and protein expression studies. [D] . Liu, Yun. 2006

机译：可卡因的刺激作用诱导成瘾和奖励参与的大脑区域中的fra-2和sigma（1）受体：来自行为，基因和蛋白质表达研究的证据。
6. Activation of spinal and supraspinal cannabinoid-1 receptors lead to antinociception in a rat model of neuropathic spinal cord injury pain [O] . Aldric Hama, Jacqueline Sagen -1

机译：脊柱和袋鼠大麻素-1受体的激活导致神经病脊髓损伤大鼠模型中的抗妇科
7. Supraspinal opioid delta receptor mediated antinociception: Supraspinal modulation of neuropathic pain [O] . Kovelowski Carl Joseph 1999

机译：上睑阿片样物质δ受体介导的抗伤害感受：上睑下调对神经性疼痛的调节

Supraspinal D_2 receptor involved in antinociception induced by l-tetrahydropalmatine

摘要

著录项

相似文献

相关主题

期刊订阅