Evidence for μ opioid receptor on mouse spleen lymphocytes

Wu Tong; Ti Xiao-Yu

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Evidence for μ opioid receptor on mouse spleen lymphocytes

机译：小鼠脾淋巴细胞中μ阿片受体的证据

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AIM: Using ohmefentanyl (Ohm), a high afinity μ opioid receptor agonist, to find whether μ opioid receptor exists on mouse spleen lymphocytes. METHODS: The proliferation rates of T-lymphocytes And B-lymphocytes were determined under various condentrations of Ohm with or without naloxone (Nal) In vitro. Binding characteristics of [~3H] Ohm with Mice spleen lymphocytes were studied by radioligand Assays. CONCLUSION: Stimulating effects of Ohm on Lymphocytes were mediated by opioid receptors. Mouse spleen lymphocytes present μ opioid receptors.

机译：目的：使用高亲和力μ阿片受体激动剂奥芬太尼（Ohm）来确定小鼠脾淋巴细胞上是否存在μ阿片受体。方法：在有或没有纳洛酮（Nal）的欧姆条件下，测定体外T淋巴细胞和B淋巴细胞的增殖率。通过放射性配体分析研究了[〜3H] Ohm与小鼠脾淋巴细胞的结合特性。结论：Ohm对淋巴细胞的刺激作用是由阿片受体介导的。小鼠脾淋巴细胞具有μ阿片受体。

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《Acta Pharmacologica Sinica》 |1999年第9期|p.835-838|共4页
作者
Wu Tong; Ti Xiao-Yu;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
fentanyl; naloxone; mu opioid receptors;

机译：芬太尼纳洛酮mu阿片受体;

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1. Up-regulation of mu-, delta- and kappa-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes [J] . Cechova Kristina, Hlouskova Martina, Javorkova Eliska, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2018,第期

机译：康西吡喃素A刺激的大鼠脾脏淋巴细胞中的MU-，DELTA-和KAPPA-APIOID受体的上调
2. The effect of restraint stress on glucocorticoid receptors in mouse spleen lymphocytes: involvement of the sympathetic nervous system. [J] . Warner A, Ovadia H, Tarcic N, Neuroimmunomodulation . 2010,第5期

机译：束缚应激对小鼠脾淋巴细胞中糖皮质激素受体的影响：交感神经系统的参与。
3. Differential kappa-opioid receptor expression on mouse lymphocytes at varying stages of maturation and on mouse macrophages after selective elicitation. [J] . Ignatowski TA, Bidlack JM The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1999,第2期

机译：选择性诱发后，小鼠淋巴细胞在成熟的不同阶段和小鼠巨噬细胞上的差异性阿片受体表达。
4. Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes [C] . Jürgen Kraus International Society for Neuroimmunomodulation . 2012

机译：μ-ApiOID受体和大麻素受体1型在T淋巴细胞中的表达和功能
5. Post-transcriptional regulation of mouse mu -opioid receptor through its 3'-UTR [D] . Wu, Qifang 2009

机译：通过其3'-UTR对小鼠mu阿片受体的转录后调控
6. The response to lipopolysaccharide of mouse spleen lymphocytes fractionated on the basis of surface immunoglobulin and complement receptor using fluorescence-activated cell sorting and rosetting techniques [O] . D. L. Brandon, A. J. Edwards, R. M. E. Parkhouse 1979

机译：基于表面免疫球蛋白和补体受体的小鼠脾淋巴细胞对脂多糖的响应采用荧光激活细胞分选和玫瑰花结技术
7. Cover Picture: The cover image features a frozen section from an embryonic day 16 mouse spleen stained by immunofluorescence to demonstrate the presence and location of lymphoid tissue inducer (LTi) cells. Witherset al. (pp. 3240–3245) show that these cells form the focus of lymphocyte accumulation in the developing mouse spleen. Red staining for CD45 marks haemopoietic cells, green shows IL-7Rα expression, and CD4 expression is in blue. LTi cells that express all markers (in white) cluster around blood vessels in the embryonic spleen where signalling to stromal cells initiates lymphocyte recruitment. – Eur. J. Immunol. 11/2007 [O] . David R. Withers, Mi-Yeon Kim, Vasileios Bekiaris, 2007

机译：封面图片：盖子图像具有来自免疫荧光染色的胚胎第16天小鼠脾脏的冷冻部分，以证明淋巴组织诱导症（LTI）细胞的存在和位置。靠近al。（第3240-3245页）表明，这些细胞在培养的小鼠脾脏中形成了淋巴细胞积累的焦点。 CD45的红色染色标记血液成对细胞，绿色显示IL-7Rα表达，CD4表达是蓝色的。 LTI细胞，其在胚胎脾脏周围表达血管周围的所有标记（白色）簇，其中信号传导到基质细胞引发淋巴细胞募集。 - 欧元。 J.Immunol。 11/2007

Evidence for μ opioid receptor on mouse spleen lymphocytes

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