Effects of S-21007, a potent 5-HT_3 partial agonist, in mouse anxiety

Philippe Delagrange; Rene Misslin; Thomas W Seale

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Effects of S-21007, a potent 5-HT_3 partial agonist, in mouse anxiety

机译：有效的5-HT_3部分激动剂S-21007对小鼠焦虑的影响

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AIM: To study the effect of S-21007, a 5-HT_3 partial agonist in different animal models of anxiety in mice. METHODS: S-21007 effects were evaluated in the behavior tests after intraperitioneal and oral acute treatment or in the light/dark test after both acute and chronic treatments. CONCLUSION: S-21007 exhibited Anxiolytic-like properties. The mechanism of action May be a desensitization of 5-HT_3 receptor or an Antagonist activity on the 5-HT_3 receptors.

机译：目的：研究5-HT_3部分激动剂S-21007在小鼠不同焦虑模型中的作用。方法：在腹膜内和口服急性治疗后的行为测试或急性和慢性治疗后的明/暗测试中评估S-21007的作用。结论：S-21007具有抗焦虑作用。作用机制可能是5-HT_3受体脱敏或对5-HT_3受体具有拮抗活性。

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《Acta Pharmacologica Sinica》 |1999年第9期|p.805-812|共8页
作者
Philippe Delagrange; Rene Misslin; Thomas W Seale;
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正文语种 eng
中图分类药理学;
关键词
S-21007; serotonin agonists; anxiety;

机译：S-21007;血清素激动剂;焦虑;

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Effects of S-21007, a potent 5-HT_3 partial agonist, in mouse anxiety

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