Effects of new constituents L-6a and L-10 from leaves of Luffa cylinderica on learning, memory, and hippocampal somatostatin in rats

QI Shang-Bin; WANG Xiao-Yang; ZHOU Yong-Lu

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Effects of new constituents L-6a and L-10 from leaves of Luffa cylinderica on learning, memory, and hippocampal somatostatin in rats

机译：丝瓜叶新成分L-6a和L-10对大鼠学习，记忆和海马生长抑素的影响

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AIM: To study the effects of two constituents L-6a and L-10 from the leaves of Luffa cylinderica Roem on learning, memory, and hippocampal somatostatin in rats. METHODS: The learning and memory in rats were determined using the passive avoidance response of shuttle-box, by icv. Somatostatin in hippocampus was determined with immunohistochemical and images analyses. RESULTS: L-6a 25 μg raised memory- keeping activity (P<0.05) in rats. L-6a 25 μg increased the surface density and number density of somatostatin-like immureactant (Som-LI) (P<0.05). L-10 25 and 50 μg increased the surface density and number density of Som-LI (P<0.05).

机译：目的：研究丝瓜叶中两种成分L-6a和L-10对大鼠学习，记忆和海马生长抑素的影响。方法：通过ICV，利用梭箱的被动回避反应来确定大鼠的学习和记忆能力。通过免疫组织化学和图像分析确定海马中的生长抑素。结果：L-6a 25μg可提高大鼠记忆力（P <0.05）。 L-6a 25μg增加了生长抑素样未反应物（Som-LI）的表面密度和数量密度（P <0.05）。 L-10 25和50μg增加了Som-LI的表面密度和数量密度（P <0.05）。

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《Acta Pharmacologica Sinica》 |1997年第6期|p.529-531|共3页
作者
QI Shang-Bin; WANG Xiao-Yang; ZHOU Yong-Lu;
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正文语种 eng
中图分类药理学;
关键词
L-6a; L-10; Luffa cylinderica Roem;

机译：L-6a;L-10;丝瓜;

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Effects of new constituents L-6a and L-10 from leaves of Luffa cylinderica on learning, memory, and hippocampal somatostatin in rats

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