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首页> 外文期刊>Advanced Functional Materials >Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
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Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications

机译：荧光纳米金刚石上支持的脂质双层：用于生物应用的结构定义和通用涂层。

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摘要

Fluorescent nanodiamonds with nitrogen-vacancy (NV) centers respond to local changes in electric and magnetic fields. These responses can be read optically as changes in fluorescence. NV centers do not suffer from photoblinking or photobleaching, making nanodiamonds a viable platform for long-term imaging of processes inside living cells. However, for any bioapplication, the surface of these particles must be modified to prevent aggregation and nonspecific protein adsorption and to effectively transduce the changes in local environment to NV center. Modular biomimetic interface has been developed on nanodiamonds with remarkable sensitivity for relaxometric readout that takes advantage of self-assembled phospholipid bilayers supported by the nanoparticle surface. This rapid and robust approach provides synthetic pathway to tunable composition, demonstrated by tuning surface charge and content of spin labels on nanodiamond. The supported phospholipid bilayer interface increases the detection sensitivity about one-order-of-magnitude. Also, a theoretical model of the system is provided, which shows excellent agreement with experimental results. Merging biocompatibility, modularity, and outstanding spin sensitivity in one nanomaterial provides a foundation for development of multifunctional nanoparticles suitable for highly sensitive monitoring of local magnetic field fluctuations and paramagnetic species under physiological conditions.
机译：具有氮空位（NV）中心的荧光纳米金刚石可响应电场和磁场的局部变化。这些反应可以作为荧光的变化光学读取。 NV中心不会遭受光闪烁或光漂白的困扰，这使纳米金刚石成为活细胞内长期过程成像的可行平台。但是，对于任何生物应用，必须对这些颗粒的表面进行修饰，以防止聚集和非特异性蛋白质吸附，并有效地将局部环境的变化传导至NV中心。模块化的仿生界面已经在纳米金刚石上开发出来，具有出色的灵敏性，可利用由纳米颗粒表面支撑的自组装磷脂双层来进行弛豫读数。这种快速而稳健的方法提供了可调谐组成的合成途径，这可通过调节纳米金刚石上的表面电荷和自旋标记的含量来证明。支持的磷脂双层界面将检测灵敏度提高了大约一个数量级。并且，提供了该系统的理论模型，其与实验结果显示出极好的一致性。在一种纳米材料中融合生物相容性，模块化和出色的自旋敏感性，为开发适用于在生理条件下高度敏感地监测局部磁场波动和顺磁性物质的多功能纳米颗粒奠定了基础。

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