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首页> 外文期刊>Advanced Functional Materials >Mitochondria- and Lysosomes-Targeted Synergistic Chemo-Photodynamic Therapy Associated with Self-Monitoring by Dual Light-Up Fluorescence
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Mitochondria- and Lysosomes-Targeted Synergistic Chemo-Photodynamic Therapy Associated with Self-Monitoring by Dual Light-Up Fluorescence

机译：线粒体和溶酶体靶向的协同化学光动力疗法与双重发光荧光的自我监测相关联。

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摘要

The current cancer therapy faces great challenges on improving the treatment efficiency and overcoming the drug resistance. To tackle these challenges, herein dual-organelle-targeted nanoparticles (NPs) are developed with synergistic chemo-photodynamic therapy functions through self-assembly of mitochondria-targeted chemotherapeutic agent AIE-Mito-TPP and lysosomes-targeted photosensitizer AlPcSNa4. The dual-organelle-targeted NPs can be quickly taken up by cancer cells through endocytosis and gradually decompose to release AIE-Mito-TPP and AlPcSNa4, which, respectively, accumulate in mitochondria and lysosomes. The AIE-Mito-TPP can efficiently destroy mitochondrial functions, while the AlPcSNa4 can efficiently destroy lysosomes via reactive oxygen species generation under NIR light irradiation. The dual-organelle-targeted drug delivery process can also be self-monitored by the dual light-up fluorescence of green-emissive AIE-Mito-TPP and red-emissive AlPcSNa4. With A375 cells and A375-bearing nude mice as a model, the theranostic potential of the AIE-Mito-TPP/AlPcSNa4 NPs is systematically investigated both in vitro and in vivo. Under NIR light irradiation, the AIE-Mito-TPP/AlPcSNa4 NPs show a remarkable cytotoxicity against A375 cells and efficiently inhibit the in vivo tumor growth. Therefore, the theranostic NPs with dual-organelle-targeted and synergistic chemo-photodynamic therapy functions associated with self-monitoring ability are expected to have promising applications in imaging-guided precise cancer therapy.
机译：当前的癌症疗法在提高治疗效率和克服耐药性方面面临巨大挑战。为了解决这些挑战，本文通过靶向线粒体的化疗剂AIE-Mito-TPP和靶向溶酶体的光敏剂AlPcSNa4的自组装，开发了具有协同化学光动力疗法功能的靶向双细胞器的纳米粒子（NP）。靶向双细胞器的NPs可以通过内吞作用迅速被癌细胞吸收，并逐渐分解以释放AIE-Mito-TPP和AlPcSNa4，它们分别在线粒体和溶酶体中蓄积。 AIE-Mito-TPP可以有效破坏线粒体功能，而AlPcSNa4可以通过在NIR光照射下生成活性氧来有效破坏溶酶体。还可以通过绿色发射AIE-Mito-TPP和红色发射AlPcSNa4的双重发光荧光来自我监测靶向双细胞器的药物递送过程。以A375细胞和带有A375的裸鼠为模型，在体外和体内系统地研究了AIE-Mito-TPP / AlPcSNa4 NP的治疗诊断潜力。在NIR光照射下，AIE-Mito-TPP / AlPcSNa4 NP对A375细胞显示出显着的细胞毒性，并有效抑制了体内肿瘤的生长。因此，具有自我监测能力的双细胞器靶向和协同化学光动力疗法功能的治疗性NP有望在影像引导的精确癌症治疗中有希望的应用。

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  • 来源
    《Advanced Functional Materials》 |2018年第44期|1804362.1-1804362.9|共9页
  • 作者

    Chen Xiaohui; Li Yunxia; Li Shiwu; Gao Meng; Ren Li; Tang Ben Zhong;

  • 作者单位

    South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China;

    South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China;

    South China Univ Technol, NSFC Ctr Luminescence Mol Aggregates, SCUT HKUST Joint Res Lab, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China;

    South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China;

    South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China;

    South China Univ Technol, NSFC Ctr Luminescence Mol Aggregates, SCUT HKUST Joint Res Lab, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    aggregation-induced emission; chemotherapy; organelle; photodynamic therapy; self-monitoring;

    机译：聚集诱导发射;化学疗法;细胞器;光动力疗法;自我监测;

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