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首页> 外文期刊>Advanced Functional Materials >Porphyrin MOF Dots-Based, Function-Adaptive Nanoplatform for Enhanced Penetration and Photodynamic Eradication of Bacterial Biofilms
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Porphyrin MOF Dots-Based, Function-Adaptive Nanoplatform for Enhanced Penetration and Photodynamic Eradication of Bacterial Biofilms

机译：基于卟啉MOF点的功能自适应纳米平台，可增强细菌生物膜的渗透和光动力消除。

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摘要

Recently, antimicrobial photodynamic therapy (aPDT) has been considered as an attractive treatment option for biofilms ablation. However, even very efficient photosensitizers (PSs) still need high light doses and PS concentrations to eliminate biofilms due to the limited penetration and diffusion of PSs in biofilms. Moreover, the hypoxic microenvironment and rapid depletion of oxygen during PDT severely limit their therapeutic effects. Herein, for the first time, a porphyrin-based metal organic framework (pMOF) dots based nanoplatform with effective biofilm penetration, self-oxygen generation, and enhanced photodynamic efficiency is synthesized for bacterial biofilms eradication. The function-adaptive nanoplatform is composed of pMOF dots encapsulated by human serum albumin coated manganese dioxide (MnO2). The pH/H2O2-responsive decomposition of MnO2 in biofilms triggers the release of ultra small and positively charged pMOF dots and simultaneously generates O-2 in situ to alleviate hypoxia for biofilms. The released pMOF dots with high reactive oxygen species yield can effectively penetrate into biofilms, strongly bind with bacterial cell surface, and ablate bacterial biofilms. Importantly, such a nano platform can realize great therapeutic outcomes for treatment of Staphylococcus aureus infected subcutaneous abscesses in vivo without damage to healthy tissues, which offers a promising strategy for efficient biofilms eradication.
机译：最近，抗菌光动力疗法（aPDT）被认为是生物膜消融的一种有吸引力的治疗选择。但是，由于PSs在生物膜中的渗透和扩散有限，即使非常高效的光敏剂（PSs）仍需要高光剂量和PS浓度才能消除生物膜。此外，PDT期间的低氧微环境和氧气的快速消耗严重限制了它们的治疗效果。本文中，首次合成了具有有效生物膜渗透性，自氧产生和增强的光动力效率的基于卟啉的金属有机骨架（pMOF）点基纳米平台，用于细菌生物膜的根除。适应功能的纳米平台由pMOF点组成，这些点被人血清白蛋白包被的二氧化锰（MnO2）封装。 pH / H2O2反应对生物膜中MnO2的分解触发了超小且带正电的pMOF点的释放，同时原位生成O-2以减轻生物膜的缺氧。释放的具有高活性氧产量的pMOF点可有效渗透到生物膜中，与细菌细胞表面牢固结合，并消融细菌生物膜。重要的是，这样的纳米平台可以在不损害健康组织的情况下实现体内治疗金黄色葡萄球菌感染的皮下脓肿的巨大治疗效果，这为有效清除生物膜提供了有希望的策略。

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  • 来源
    《Advanced Functional Materials》 |2019年第30期|1903018.1-1903018.9|共9页
  • 作者

    Deng Qingqing; Sun Panpan; Zhang Lu; Liu Zhengwei; Wang Huan; Ren Jinsong; Qu Xiaogang;

  • 作者单位

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China|Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China|Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China|Univ Chinese Acad Sci, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China|Univ Chinese Acad Sci, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China|Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    biofilms eradication; biofilms penetration; enhanced photodynamic efficacy; MOF dots;

    机译：生物膜消除;生物膜渗透;增强光动力学效果;MOF点;

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