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Improved Gastric Acid Resistance and Adhesive Colonization of Probiotics by Mucoadhesive and Intestinal Targeted Konjac Glucomannan Microspheres

机译：通过粘膜粘附和肠道靶向康奈曼甘露甘露甘露甘露甘露甘露甘露甘露甘露甘露甘露甘草微球改善胃酸抗性和益生菌粘附殖民

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摘要

The low survival rate in harsh stomach conditions and short retention in intestine of probiotics greatly limit their health benefits. To solve this problem, thiolated oxidized konjac glucomannan (sOKGM) microspheres is designed with pH responsive and mucoadhesive properties. First, an increased survival rate of probiotics by sOKGM microspheres encapsulation in simulated gastric fluid (SGF) is discovered in contrast to the zero-survival rate of naked probiotics. sOKGM/probiotics even show a higher survival rate in SGF compared with commercial Bb12 formulation. Further, an enhanced mucoadhesion of probiotics to intestinal mucus by mediated interactions with sOKGM is confirmed by isotherm titration calorimetry, rheology, and tensile measurements. The in vivo intestinal transition experiment indicates a prolonged retention of probiotics at intestine by sOKGM encapsulation. Moreover, in vivo evaluation of enhanced colonization and proliferation by sOKGM/probiotics is demonstrated by the fecal and intestinal bacteria copy number via quantitative polymerase chain reaction (qPCR) detection. Further investigation of the alleviation of constipation by sOKGM containingBifidobacterium animalissubsp.lactisA6 suggests that sOKGM increases the abundance ofBifidobacterium, balanced intestinal flora, and alleviated constipation in mice compared with other formulations. sOKGM with both enhanced gastric acid resistance and adhesion colonization at intestine can effectively improve the function of probiotics.
机译：肥胖胃条件下的低生存率和益生菌肠道的短暂保留极大地限制了他们的健康益处。为了解决这个问题，硫醇化的氧化康奈曼葡糖胺（Sokgm）微球设计有pH响应性和粘膜粘附性。首先，与裸益生菌的零存活率相比，发现了益生菌的益生菌的存活率增加，与裸体益生菌的零存活率相反。与商业BB12配方相比，Sokgm /益生菌甚至在SGF中显示出更高的存活率。此外，通过介导的与Sokgm相互作用，通过等温滴定热量，流变学和拉伸测量来证实益生菌对肠粘膜的增强粘膜。体内肠道过渡实验表明Sokgm封装在肠道延长了益生菌的延长保留。此外，通过定量聚合酶链式反应（QPCR）检测，通过粪便和肠道细菌拷贝数证明了Sokgm /益生菌的增强的定植和增殖的体内评估。进一步调查Sokgm含有非含比杆菌的甲状腺磷酸杆菌的便秘的研究表明，与其他配方相比，Sokgm增加了大量的抗菌，平衡肠道菌群，缓解小鼠的便秘。 Sokgm具有增强的胃酸抗性和肠道粘附定子，可以有效地改善益生菌的功能。

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  • 来源
    《Advanced Functional Materials》 |2020年第35期|2001157.1-2001157.11|共11页
  • 作者

    Liu Ying; Liu Bin; Li Dan; Hu Yulin; Zhao Liang; Zhang Ming; Ge Shaoyang; Pang Jie; Li Yixuan; Wang Ran; Wang Pengjie; Huang Yutao; Huang Jing; Bai Jie; Ren Fazheng; Li Yuan;

  • 作者单位

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    Beijing Technol & Business Univ Sch Food & Hlth Beijing 100048 Peoples R China;

    China Agr Univ Res Ctr Probiot Baoding 065201 Hebei Peoples R China;

    Fujian Agr & Forestry Univ Coll Food Sci Fuzhou 350002 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China|China Agr Univ Res Ctr Probiot Baoding 065201 Hebei Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

    China Agr Univ Coll Food Sci & Nutr Engn Key Lab Precis Nutr & Food Qual Key Lab Funct Dairy Minist Educ Beijing 100083 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    constipation alleviation; gastric acid resistance; mucoadhesion; oxidized konjac glucomannan; probiotics;

    机译：便秘缓解;胃酸抗性;粘液粘附;氧化康奈克葡甘松南诺;益生菌;

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