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Bioswitchable Antibacterial Coatings Enable Self- Sterilization of Implantable Healthcare Dressings

机译：BioSwockable抗菌涂料可以自杀植入医疗保健敷料

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摘要

Healthcare-acquired bacterial infections are a threat to public health. Therefore, development of self-sterilizing implantable dressing materials is in increasing demand. Herein, a series of quaternized triblock copolymers, namely, QP-b-PCL-b-QPs, are synthesized and self-assembled into reverse micelles (RMs) in tetrahydrofuran. The RMs contain biocompatible poly(epsilon-caprolactone) (PCL) blocks in the shell to render biosafety and responsiveness, and biocidal quaternary blocks in the core to render antibacterial activity. In the presence of bacterial lipase, the biodegradable PCL blocks are hydrolyzed, resulting in the responsive release of quaternary biocidal agents (QBAs) to enable self-sterilization. The RMs can be facilely impregnated into commercial gelatin sponge (GS) to fabricate RM2-coated GS, which impose potent antibacterial activity in the presence of lipase. Compared to Gram-negative P. aeruginosa, the Gram-positive S. aureus and B. subtilis are more susceptible to QBAs released from RM2-coated GS. The in vivo antibacterial assays and histological analyses further confirm the validity of RM2-coated GS in reducing bacterial infection in mice model. These results, taken together, provide a promising strategy for the development of bioswitchable self-sterilizing dressing materials to reduce healthcare-acquired bacterial infections.
机译：医疗保健的细菌感染是对公共卫生的威胁。因此，开发自杀植入敷料材料的需求越来越大。这里，一系列季铵化三嵌段共聚物，即QP-B-PCL-B-QP，合成并自组装成四氢呋喃中的反向胶束（RMS）。该RMS含有在壳中的生物相容性聚（ε-己内酯）（PCL）嵌段，以使生物安全和反应性，核心中的生物杀菌性季嵌段呈现出抗菌活性。在细菌脂肪酶的存在下，可生物降解的PCL嵌段是水解的，导致季杀酶杀生物剂（QBAs）的响应释放，以实现自灭菌。 RMS可以浸渍到商业明胶海绵（GS）中以制造RM2涂覆的GS，其在脂肪酶存在下施加有效的抗菌活性。与Gram阴性P.铜绿假单胞菌相比，革兰氏阳性的金黄色葡萄球菌和B.枯草芽孢杆菌更容易受到RM2涂覆的GS释放的QBAS。体内抗菌测定和组织学分析进一步证实了RM2涂覆GS在降低小鼠模型中的细菌感染方面的有效性。这些结果，一起参加，为生物排水的自杀菌敷料材料开发提供了有希望的策略，以减少医疗保健获得的细菌感染。

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  • 来源
    《Advanced Functional Materials》 |2021年第18期|2011165.1-2011165.12|共12页
  • 作者

    Wang Anzhi; Duan Shun; Ding Xuejia; Zhao Nana; Hu Yang; Ding Xiaokang; Xu Fu-Jian;

  • 作者单位

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

    Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Key Lab Biomed M Minist Educ Beijing Lab Biomed Mat Coll Mat Sci & Beijing 100029 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    antibacterial gelatin sponge; bioswitchable self#8208; sterilization; implantable healthcare dressing; lipase responsive; reverse micelle;

    机译：抗菌明胶海绵;生物开关的自杀;植入医疗保健敷料;脂肪酶响应;反向胶束;

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