• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Plant-Based Hollow Microcapsules for Oral Delivery Applications: Toward Optimized Loading and Controlled Release
【24h】

Plant-Based Hollow Microcapsules for Oral Delivery Applications: Toward Optimized Loading and Controlled Release

机译：用于口服给药的基于植物的中空微胶囊：优化载药量和控制释放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Efficient oral administration of protein-based therapeutics faces significant challenges due to degradation from the highly acidic conditions present in the stomach and proteases present in the digestive tract. Herein, investigations into spike-covered sunflower sporopollenin exine capsules (SECs) for oral protein delivery using bovine serum albumin (BSA) as a model drug are reported and provide significant insights into the optimization of SEC extraction, SEC loading, and controlled release. The phosphoric-acid-based SEC extraction process is optimized. Compound loading is shown to be driven by the evacuation of air bubbles from SEC cavities through the porous SEC shell wall, and vacuum loading is shown to be the optimal loading method. Three initial BSA-loading proportions are evaluated, leading to a practical loading efficiency of 22.3 +/- 1.5 wt% and the determination that the theoretical maximum loading is 46.4 +/- 2.5 wt%. Finally, an oral delivery formulation for targeted intestinal delivery is developed by tableting BSA-loaded SECs and enteric coating. BSA release is inhibited for 2 h in simulated gastric conditions followed by 100% release within 8 h in simulated intestinal conditions. Collectively, these results indicate that sunflower SECs provide a versatile platform for the oral delivery of therapeutics.
机译：由于胃中存在的高酸性条件导致的降解以及消化道中存在的蛋白酶的降解，基于蛋白质的治疗剂的有效口服给药面临着巨大的挑战。本文中，对使用牛血清白蛋白（BSA）作为模型药物进行口服蛋白递送的穗状花序孢子粉花青素外膜胶囊（SECs）的研究进行了报道，并为SEC提取的优化，SEC负载和控释提供了重要的见识。对基于磷酸的SEC萃取工艺进行了优化。已显示化合物加载是通过从SEC腔中通过多孔SEC壳壁抽空气泡来驱动的，真空加载是最佳的加载方法。评估了三个初始BSA负载比例，从而得出了22.3 +/- 1.5 wt％的实际负载效率，并确定了理论上的最大负载为46.4 +/- 2.5 wt％。最终，通过压片加载BSA的SEC和肠溶衣开发了靶向肠递送的口服递送制剂。在模拟的胃条件下，BSA释放被抑制2小时，随后在模拟的肠条件下，BSA释放在8小时内被100％释放。总的来说，这些结果表明向日葵SEC提供了用于口服治疗剂的通用平台。

著录项

  • 来源
    《Advanced Functional Materials》 |2017年第31期|1700270.1-1700270.12|共12页
  • 作者

    Potroz Michael G.; Mundargi Raghavendra C.; Gillissen Jurriaan J.; Tan Ee-Lin; Meker Sigalit; Park Jae H.; Jung Haram; Park Soohyun; Cho Daeho; Bang Sa-Ik; Cho Nam-Joon;

  • 作者单位

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Sookmyung Womens Univ, Dept Cosmet Sci, Seoul 140742, South Korea;

    Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, 50 Ilwon Dong, Seoul 135710, South Korea;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore|Nanyang Technol Univ, Sch Chem & Biomed Engn, 62 Nanyang Dr, Singapore 637459, Singapore;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    oral delivery; protein delivery; sporopollenin exine capsules (SECs); sunflower pollen; targeted intestinal delivery;

    机译：口服递送;蛋白质递送;孢粉外泌胶囊（SECs）;向日葵花粉;靶向肠递送;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号