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3D Printing of Bilineage Constructive Biomaterials for Bone and Cartilage Regeneration

机译：用于骨骼和软骨再生的双系构建生物材料的3D打印

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摘要

Owing to the different biological properties of articular cartilage and subchondral bone, it remains significant challenge to construct a bi-lineage constructive scaffold. In this study, manganese (Mn)-doped beta-TCP (Mn-TCP) scaffolds with varied Mn contents are prepared by a 3D-printing technology. The effects of Mn on the physicochemical properties, bioactivity, and corresponding mechanism for stimulating osteochondral regeneration are systematically investigated. The incorporation of Mn into beta-TCP lowers the lattices parameters and crystallization temperatures, but improves the scaffold density and compressive strength. The ionic products from Mn-TCP significantly improve the proliferation of both rabbit chondrocytes and mesenchymal stem cells (rBMSCs), as well as promote the differentiation of chondrocytes and rBMSCs. The in vivo study shows that Mn-TCP scaffolds distinctly improve the regeneration of subchondral bone and cartilage tissues as compared to TCP scaffolds, upon transplantation in rabbit osteochondral defects for 8 and 12 weeks. The mechanism is closely related to the Mn2+ ions significantly stimulated the proliferation and differentiation of chondrocytes through activating HIF pathway and protected chondrocytes from the inflammatory osteoarthritis environment by activating autophagy. These findings suggest that 3D-printing of Mn-containing scaffolds with improved physicochemical properties and bilineage bioactivities represents an intelligent strategy for regenerating osteochondral defects.
机译：由于关节软骨和软骨下骨的不同生物学特性，构建双谱系构建支架仍然是重大挑战。在这项研究中，通过3D打印技术制备了具有不同Mn含量的锰（Mn）掺杂的β-TCP（Mn-TCP）支架。系统地研究了锰对理化性质，生物活性以及刺激骨软骨再生的相应机理的影响。 Mn掺入β-TCP可以降低晶格参数和结晶温度，但可以提高支架密度和抗压强度。 Mn-TCP的离子产物可显着改善兔软骨细胞和间充质干细胞（rBMSC）的增殖，并促进软骨细胞和rBMSC的分化。体内研究表明，与TCP支架相比，Mn-TCP支架在移植兔骨软骨缺损8周和12周后，可显着改善软骨下骨和软骨组织的再生。该机制与Mn2 +离子通过激活HIF途径显着刺激软骨细胞的增殖和分化以及通过激活自噬保护软骨细胞免受炎性骨关节炎环境密切相关。这些发现表明，具有改善的理化性质和双线性生物活性的含锰支架的3D打印代表了再生骨软骨缺损的明智策略。

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  • 来源
    《Advanced Functional Materials》 |2017年第36期|1703117.1-1703117.14|共14页
  • 作者

    Deng Cuijun; Yao Qingqiang; Feng Chun; Li Jiayi; Wang Liming; Cheng Guofeng; Shi Mengchao; Chen Lei; Chang Jiang; Wu Chengtie;

  • 作者单位

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Nanjing Med Univ, Dept Orthopaed Surg, Digital Med Inst, Nanjing Hosp, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Nanjing Med Univ, Dept Orthopaed Surg, Digital Med Inst, Nanjing Hosp, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China;

    Nanjing Med Univ, Dept Orthopaed Surg, Digital Med Inst, Nanjing Hosp, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    3D-printing; bilineage; cartilage; manganese; regeneration;

    机译：3D打印;双谱系;软骨;锰;再生;

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