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首页> 外文期刊>Advanced Functional Materials >Boronic Acid Decorated Defective Metal-Organic Framework Nanoreactors for High-Efficiency Carbohydrates Separation and Labeling
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Boronic Acid Decorated Defective Metal-Organic Framework Nanoreactors for High-Efficiency Carbohydrates Separation and Labeling

机译：硼酸修饰的有缺陷的金属有机骨架纳米反应器，用于高效碳水化合物的分离和标记

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摘要

Separation and labeling are the crucial steps for the carbohydrates identification and detection in the important field of biochemistry, biomedicine, glycomics, and glycobiology. Herein, for the first time, a boronic acid decorated defective metal-organic framework (B-D-MI-100) nanoreactor is designed, which integrates fast separation and labeling of carbohydrates into one step. Without the sacrifice of internal room space, the incorporation of abundant functional boronic acid groups into the framework is achieved through metal-ligand-fragment coassembly strategy. And the novel solid phase orientation labeling approach performed within elaborate Cr based B-D-MIL-100 nanoreactor is facile to avoid the conformation transition of carbohydrates occurred in classical liquid-phase labeling. As a result, the novel approach presents several merits, including high separation efficiency (almost all of the incorporated boronic acid groups are available), much fast labeling reaction speed (labeling reaction time is decreased from 7 h to 3 min), high purity of the product, and three orders of magnitude lower applicable carbohydrate concentration for labeling. Thus, this new approach advances the idea to efficiently detect and identify trace carbohydrates in important fields such as glycomics and glycobiology.
机译：在生物化学，生物医学，糖组学和糖生物学的重要领域，分离和标记是碳水化合物鉴定和检测的关键步骤。本文中，首次设计了硼酸修饰的有缺陷的金属有机骨架（B-D-MI-100）纳米反应器，它将碳水化合物的快速分离和标记整合到一个步骤中。在不牺牲内部空间的情况下，通过金属-配体-片段共组装策略实现了将丰富的功能性硼酸基团引入框架。并且，在复杂的基于Cr的B-D-MIL-100纳米反应器中进行的新颖固相取向标记方法易于避免在经典液相标记中发生的碳水化合物的构象转变。结果，这种新方法具有多种优点，包括分离效率高（几乎所有结合的硼酸基团都可用），标记反应速度快（标记反应时间从7小时减少至3分钟），产品，将适用的碳水化合物浓度降低三个数量级以进行标记。因此，这种新方法提出了有效检测和鉴定重要领域（例如糖组学和糖生物学）中痕量碳水化合物的想法。

著录项

  • 来源
    《Advanced Functional Materials》 |2017年第38期|1702126.1-1702126.9|共9页
  • 作者

    Chen Guosheng; Fang Xuan; Chen Qing; Zhang Jinge; Zhong Zhensong; Xu Jianqiao; Zhu Fang; Ouyang Gangfeng;

  • 作者单位

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    boronic acid; carbohydrates; labeling; metal-organic frameworks; nanoreactors;

    机译：硼酸;碳水化合物;标记;金属有机骨架;纳米反应器;

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